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Expression of Long Noncoding RNA YIYA Promotes Glycolysis in Breast Cancer.

Publication ,  Journal Article
Xing, Z; Zhang, Y; Liang, K; Yan, L; Xiang, Y; Li, C; Hu, Q; Jin, F; Putluri, V; Putluri, N; Coarfa, C; Sreekumar, A; Park, PK; Nguyen, TK ...
Published in: Cancer Res
August 15, 2018

Long noncoding RNA (lncRNA) is yet to be linked to cancer metabolism. Here, we report that upregulation of the lncRNA LINC00538 (YIYA) promotes glycolysis, cell proliferation, and tumor growth in breast cancer. YIYA is associated with the cytosolic cyclin-dependent kinase CDK6 and regulated CDK6-dependent phosphorylation of the fructose bisphosphatase PFK2 (PFKFB3) in a cell-cycle-independent manner. In breast cancer cells, these events promoted catalysis of glucose 6-phosphate to fructose-2,6-bisphosphate/fructose-1,6-bisphosphate. CRISPR/Cas9-mediated deletion of YIYA or CDK6 silencing impaired glycolysis and tumor growth in vivo In clinical specimens of breast cancer, YIYA was expressed in approximately 40% of cases where it correlated with CDK6 expression and unfavorable survival outcomes. Our results define a functional role for lncRNA in metabolic reprogramming in cancer, with potential clinical implications for its therapeutic targeting.Significance: These findings offer a first glimpse into how a long-coding RNA influences cancer metabolism to drive tumor growth. Cancer Res; 78(16); 4524-32. ©2018 AACR.

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Published In

Cancer Res

DOI

EISSN

1538-7445

Publication Date

August 15, 2018

Volume

78

Issue

16

Start / End Page

4524 / 4532

Location

United States

Related Subject Headings

  • RNA, Long Noncoding
  • Phosphorylation
  • Oncology & Carcinogenesis
  • Humans
  • Glycolysis
  • Glucose
  • Gene Expression Regulation, Neoplastic
  • Female
  • Cyclin-Dependent Kinase 6
  • Cell Proliferation
 

Citation

APA
Chicago
ICMJE
MLA
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Xing, Z., Zhang, Y., Liang, K., Yan, L., Xiang, Y., Li, C., … Lin, C. (2018). Expression of Long Noncoding RNA YIYA Promotes Glycolysis in Breast Cancer. Cancer Res, 78(16), 4524–4532. https://doi.org/10.1158/0008-5472.CAN-17-0385
Xing, Zhen, Yanyan Zhang, Ke Liang, Liang Yan, Yu Xiang, Chunlai Li, Qingsong Hu, et al. “Expression of Long Noncoding RNA YIYA Promotes Glycolysis in Breast Cancer.Cancer Res 78, no. 16 (August 15, 2018): 4524–32. https://doi.org/10.1158/0008-5472.CAN-17-0385.
Xing Z, Zhang Y, Liang K, Yan L, Xiang Y, Li C, et al. Expression of Long Noncoding RNA YIYA Promotes Glycolysis in Breast Cancer. Cancer Res. 2018 Aug 15;78(16):4524–32.
Xing, Zhen, et al. “Expression of Long Noncoding RNA YIYA Promotes Glycolysis in Breast Cancer.Cancer Res, vol. 78, no. 16, Aug. 2018, pp. 4524–32. Pubmed, doi:10.1158/0008-5472.CAN-17-0385.
Xing Z, Zhang Y, Liang K, Yan L, Xiang Y, Li C, Hu Q, Jin F, Putluri V, Putluri N, Coarfa C, Sreekumar A, Park PK, Nguyen TK, Wang S, Zhou J, Zhou Y, Marks JR, Hawke DH, Hung M-C, Yang L, Han L, Ying H, Lin C. Expression of Long Noncoding RNA YIYA Promotes Glycolysis in Breast Cancer. Cancer Res. 2018 Aug 15;78(16):4524–4532.

Published In

Cancer Res

DOI

EISSN

1538-7445

Publication Date

August 15, 2018

Volume

78

Issue

16

Start / End Page

4524 / 4532

Location

United States

Related Subject Headings

  • RNA, Long Noncoding
  • Phosphorylation
  • Oncology & Carcinogenesis
  • Humans
  • Glycolysis
  • Glucose
  • Gene Expression Regulation, Neoplastic
  • Female
  • Cyclin-Dependent Kinase 6
  • Cell Proliferation