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Motor activity and quantitative autoradiographic analysis of muscarinic receptors in the brain of rats subjected to the forced swimming test.

Publication ,  Journal Article
Carrizo, E; Cano, G; Suarez-Roca, H; Bonilla, E
Published in: Brain research bulletin
January 1997

A cholinergic dysfunction has been involved in the neurobiological mechanisms of stress and depression. In the present study, we determined the autoradiographic distribution of muscarinic cholinergic receptors in the brain of rats subjected to the forced swimming test for 15 days. Motor activity was automatically analyzed daily before swimming. In the forced swimming test group, both total horizontal activity and ambulatory movements exhibited a significant decrease, when the data from 1st and 15th day were compared. Neither the affinity of [3H]-quinuclidinyl benzilate nor the maximal number of receptors were affected by the forced swimming test in the caudate-putamen, cortex, and hippocampus. The distribution of [3H]-quinuclidinyl benzilate binding sites did not show significant differences in the 30 analyzed areas. Further analysis of muscarinic receptor subtypes after forced swimming test would be necessary to discard any cholinergic involvement.

Duke Scholars

Published In

Brain research bulletin

DOI

EISSN

1873-2747

ISSN

0361-9230

Publication Date

January 1997

Volume

42

Issue

2

Start / End Page

133 / 139

Related Subject Headings

  • Tissue Distribution
  • Swimming
  • Stress, Physiological
  • Receptors, Muscarinic
  • Rats, Sprague-Dawley
  • Rats
  • Quinuclidinyl Benzilate
  • Neurology & Neurosurgery
  • Motor Activity
  • Male
 

Citation

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Chicago
ICMJE
MLA
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Carrizo, E., Cano, G., Suarez-Roca, H., & Bonilla, E. (1997). Motor activity and quantitative autoradiographic analysis of muscarinic receptors in the brain of rats subjected to the forced swimming test. Brain Research Bulletin, 42(2), 133–139. https://doi.org/10.1016/s0361-9230(96)00226-2
Carrizo, E., G. Cano, H. Suarez-Roca, and E. Bonilla. “Motor activity and quantitative autoradiographic analysis of muscarinic receptors in the brain of rats subjected to the forced swimming test.Brain Research Bulletin 42, no. 2 (January 1997): 133–39. https://doi.org/10.1016/s0361-9230(96)00226-2.
Carrizo E, Cano G, Suarez-Roca H, Bonilla E. Motor activity and quantitative autoradiographic analysis of muscarinic receptors in the brain of rats subjected to the forced swimming test. Brain research bulletin. 1997 Jan;42(2):133–9.
Carrizo, E., et al. “Motor activity and quantitative autoradiographic analysis of muscarinic receptors in the brain of rats subjected to the forced swimming test.Brain Research Bulletin, vol. 42, no. 2, Jan. 1997, pp. 133–39. Epmc, doi:10.1016/s0361-9230(96)00226-2.
Carrizo E, Cano G, Suarez-Roca H, Bonilla E. Motor activity and quantitative autoradiographic analysis of muscarinic receptors in the brain of rats subjected to the forced swimming test. Brain research bulletin. 1997 Jan;42(2):133–139.
Journal cover image

Published In

Brain research bulletin

DOI

EISSN

1873-2747

ISSN

0361-9230

Publication Date

January 1997

Volume

42

Issue

2

Start / End Page

133 / 139

Related Subject Headings

  • Tissue Distribution
  • Swimming
  • Stress, Physiological
  • Receptors, Muscarinic
  • Rats, Sprague-Dawley
  • Rats
  • Quinuclidinyl Benzilate
  • Neurology & Neurosurgery
  • Motor Activity
  • Male