Skip to main content
Journal cover image

Post-irradiation morphoea of the breast: a case report and review of the literature.

Publication ,  Journal Article
Gonzalez-Ericsson, PI; Estrada, MV; Al-Rohil, R; Sanders, ME
Published in: Histopathology
January 2018

We describe a 44-year-old female with triple-negative breast cancer who developed skin erythaema, sclerosis and contracture of her entire right breast 15 months after completion of post-lumpectomy chemotherapy and radiotherapy, consistent with post-irradiation morphoea (PIM). PIM is a rare complication of breast irradiation that impairs a patient's quality of life. PIM is located usually at the radiation port or in the surrounding tissue. Clinically, PIM is misdiagnosed commonly as lymphoedema and cellulitis in the early inflammatory phase, and recurrent breast cancer, chronic radiodermatitis (CRD), radiation-induced fibrosis (RIF), post-irradiation pseudosclerodermatous panniculitis (PIPP), atypical vascular lesions (AVL) or angiosarcoma (AS) in the late burnout phase. Arriving at the correct diagnosis typically requires a multidisciplinary approach, including a skin biopsy for confirmation. To date, satisfactory treatment of this condition has been challenging. and the clinical outcome after therapy is often unsatisfactory.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Histopathology

DOI

EISSN

1365-2559

Publication Date

January 2018

Volume

72

Issue

2

Start / End Page

342 / 350

Location

England

Related Subject Headings

  • Triple Negative Breast Neoplasms
  • Scleroderma, Localized
  • Radiation Injuries
  • Pathology
  • Humans
  • Female
  • Adult
  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gonzalez-Ericsson, P. I., Estrada, M. V., Al-Rohil, R., & Sanders, M. E. (2018). Post-irradiation morphoea of the breast: a case report and review of the literature. Histopathology, 72(2), 342–350. https://doi.org/10.1111/his.13343
Gonzalez-Ericsson, Paula I., Monica V. Estrada, Rami Al-Rohil, and Melinda E. Sanders. “Post-irradiation morphoea of the breast: a case report and review of the literature.Histopathology 72, no. 2 (January 2018): 342–50. https://doi.org/10.1111/his.13343.
Gonzalez-Ericsson PI, Estrada MV, Al-Rohil R, Sanders ME. Post-irradiation morphoea of the breast: a case report and review of the literature. Histopathology. 2018 Jan;72(2):342–50.
Gonzalez-Ericsson, Paula I., et al. “Post-irradiation morphoea of the breast: a case report and review of the literature.Histopathology, vol. 72, no. 2, Jan. 2018, pp. 342–50. Pubmed, doi:10.1111/his.13343.
Gonzalez-Ericsson PI, Estrada MV, Al-Rohil R, Sanders ME. Post-irradiation morphoea of the breast: a case report and review of the literature. Histopathology. 2018 Jan;72(2):342–350.
Journal cover image

Published In

Histopathology

DOI

EISSN

1365-2559

Publication Date

January 2018

Volume

72

Issue

2

Start / End Page

342 / 350

Location

England

Related Subject Headings

  • Triple Negative Breast Neoplasms
  • Scleroderma, Localized
  • Radiation Injuries
  • Pathology
  • Humans
  • Female
  • Adult
  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences
  • 1103 Clinical Sciences