Co-occurring reasons for medication nonadherence within subgroups of patients with hyperlipidemia.
Medication nonadherence is a significant clinical problem among individuals taking statins. Poor adherence is often attributable to several reasons, yet most adherence interventions target a single reason. Baseline data were examined from a randomized clinical trial of 236 patients with hyperlipidemia. A latent class analysis was then performed on patients reporting any nonadherence (n = 109). A 4-class solution provided the most optimal fit and differentiation of classes. Class 1 (N = 59, 54%) included patients who reported occasionally forgetting. Class 2 (N = 16, 14%) represented patients who were concerned about side effects. Class 3 (N = 17, 16%) represented patients who reported out-of-routine life events as contributing to nonadherence. Class 4 (N = 17, 16%) represented patients who endorsed a large number reasons indiscriminately. Class membership was almost uniformly unrelated to any patient demographic factors or treatment arm. Each cluster of reasons defining these patients may be best addressed through different intervention strategies.
Duke Scholars
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- Middle Aged
- Medication Adherence
- Male
- Hyperlipidemias
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Humans
- Female
- Cross-Sectional Studies
- Clinical Psychology
- Aged
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Middle Aged
- Medication Adherence
- Male
- Hyperlipidemias
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Humans
- Female
- Cross-Sectional Studies
- Clinical Psychology
- Aged