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Novel intranasal pertussis vaccine based on bacterium-like particles as a mucosal adjuvant.

Publication ,  Journal Article
Shi, W; Kou, Y; Jiang, H; Gao, F; Kong, W; Su, W; Xu, F; Jiang, C
Published in: Immunol Lett
June 2018

Pertussis, or whooping cough, has recently reemerged as a major public health threat despite high levels of vaccination. The development of a novel pertussis vaccine, especially an intranasal (i.n.) vaccine is undoubtedly necessary, and mucosal adjuvants have been explored to enhance the immune response. In the present study, bacterium-like particles (BLPs) were adopted as a mucosal adjuvant for an i.n. pertussis vaccine and evaluated on the ability to induce serum and mucosal antibodies as well as potency against i.n. challenge in mice. Groups with or without aluminum adjuvant were also evaluated through both i.n. and intraperitoneal inoculations. Vaccination with BLPs via the i.n. route led to rapid IgG and IgA production and provided strong protection against inflammation induced by infection. The results support an i.n. pertussis vaccine with BLPs adjuvant as a promising candidate to elicit protective immunity against whooping cough.

Duke Scholars

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Published In

Immunol Lett

DOI

EISSN

1879-0542

Publication Date

June 2018

Volume

198

Start / End Page

26 / 32

Location

Netherlands

Related Subject Headings

  • Whooping Cough
  • Pertussis Vaccine
  • Nasopharynx
  • Mucous Membrane
  • Mice, Inbred BALB C
  • Lung
  • Immunology
  • Immunoglobulin G
  • Immunoglobulin A
  • Immunity, Mucosal
 

Citation

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Shi, W., Kou, Y., Jiang, H., Gao, F., Kong, W., Su, W., … Jiang, C. (2018). Novel intranasal pertussis vaccine based on bacterium-like particles as a mucosal adjuvant. Immunol Lett, 198, 26–32. https://doi.org/10.1016/j.imlet.2018.03.012
Shi, Wei, Yiming Kou, Hao Jiang, Feng Gao, Wei Kong, Weiheng Su, Fei Xu, and Chunlai Jiang. “Novel intranasal pertussis vaccine based on bacterium-like particles as a mucosal adjuvant.Immunol Lett 198 (June 2018): 26–32. https://doi.org/10.1016/j.imlet.2018.03.012.
Shi W, Kou Y, Jiang H, Gao F, Kong W, Su W, et al. Novel intranasal pertussis vaccine based on bacterium-like particles as a mucosal adjuvant. Immunol Lett. 2018 Jun;198:26–32.
Shi, Wei, et al. “Novel intranasal pertussis vaccine based on bacterium-like particles as a mucosal adjuvant.Immunol Lett, vol. 198, June 2018, pp. 26–32. Pubmed, doi:10.1016/j.imlet.2018.03.012.
Shi W, Kou Y, Jiang H, Gao F, Kong W, Su W, Xu F, Jiang C. Novel intranasal pertussis vaccine based on bacterium-like particles as a mucosal adjuvant. Immunol Lett. 2018 Jun;198:26–32.
Journal cover image

Published In

Immunol Lett

DOI

EISSN

1879-0542

Publication Date

June 2018

Volume

198

Start / End Page

26 / 32

Location

Netherlands

Related Subject Headings

  • Whooping Cough
  • Pertussis Vaccine
  • Nasopharynx
  • Mucous Membrane
  • Mice, Inbred BALB C
  • Lung
  • Immunology
  • Immunoglobulin G
  • Immunoglobulin A
  • Immunity, Mucosal