Skip to main content
Journal cover image

Evaluation of recombinant adenovirus vaccines based on glycoprotein D and truncated UL25 against herpes simplex virus type 2 in mice.

Publication ,  Journal Article
Liu, W; Zhou, Y; Wang, Z; Zhang, Z; Wang, Q; Su, W; Chen, Y; Zhang, Y; Gao, F; Jiang, C; Kong, W
Published in: Microbiol Immunol
May 2017

The high prevalence of herpes simplex virus 2 (HSV-2) infections in humans necessitates the development of a safe and effective vaccine that will need to induce vigorous T-cell responses to control viral infection and transmission. We designed rAd-gD2, rAd-gD2ΔUL25, and rAd-ΔUL25 to investigate whether recombinant replication-defective adenoviruses vaccine could induce specific T-cell responses and protect mice against intravaginal HSV-2 challenge compared with FI-HSV-2. In the present study, recombinant adenovirus-based HSV-2 showed higher reductions in mortality and stronger antigen-specific T-cell responses compared with FI-HSV-2 and the severity of genital lesions in mice immunized with rAd-gD2ΔUL25 was significantly decreased by eliciting IFN-γ-secreting T-cell responses compared with rAd-gD2 and rAd-ΔUL25 groups. Our results demonstrated the immunogenicity and protective efficacy of recombinant adenovirus vaccines in acute HSV-2 infection following intravaginal challenge in mice.

Duke Scholars

Published In

Microbiol Immunol

DOI

EISSN

1348-0421

Publication Date

May 2017

Volume

61

Issue

5

Start / End Page

176 / 184

Location

Australia

Related Subject Headings

  • Viral Envelope Proteins
  • Vaccines, Synthetic
  • Microbiology
  • Mice, Inbred BALB C
  • Mice
  • Interferon-gamma
  • Herpesvirus 2, Human
  • Herpes Genitalis
  • Glycoproteins
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Liu, W., Zhou, Y., Wang, Z., Zhang, Z., Wang, Q., Su, W., … Kong, W. (2017). Evaluation of recombinant adenovirus vaccines based on glycoprotein D and truncated UL25 against herpes simplex virus type 2 in mice. Microbiol Immunol, 61(5), 176–184. https://doi.org/10.1111/1348-0421.12482
Liu, Wei, Yan Zhou, Ziyan Wang, Zeqiang Zhang, Qizhi Wang, Weiheng Su, Yan Chen, et al. “Evaluation of recombinant adenovirus vaccines based on glycoprotein D and truncated UL25 against herpes simplex virus type 2 in mice.Microbiol Immunol 61, no. 5 (May 2017): 176–84. https://doi.org/10.1111/1348-0421.12482.
Liu W, Zhou Y, Wang Z, Zhang Z, Wang Q, Su W, et al. Evaluation of recombinant adenovirus vaccines based on glycoprotein D and truncated UL25 against herpes simplex virus type 2 in mice. Microbiol Immunol. 2017 May;61(5):176–84.
Liu, Wei, et al. “Evaluation of recombinant adenovirus vaccines based on glycoprotein D and truncated UL25 against herpes simplex virus type 2 in mice.Microbiol Immunol, vol. 61, no. 5, May 2017, pp. 176–84. Pubmed, doi:10.1111/1348-0421.12482.
Liu W, Zhou Y, Wang Z, Zhang Z, Wang Q, Su W, Chen Y, Zhang Y, Gao F, Jiang C, Kong W. Evaluation of recombinant adenovirus vaccines based on glycoprotein D and truncated UL25 against herpes simplex virus type 2 in mice. Microbiol Immunol. 2017 May;61(5):176–184.
Journal cover image

Published In

Microbiol Immunol

DOI

EISSN

1348-0421

Publication Date

May 2017

Volume

61

Issue

5

Start / End Page

176 / 184

Location

Australia

Related Subject Headings

  • Viral Envelope Proteins
  • Vaccines, Synthetic
  • Microbiology
  • Mice, Inbred BALB C
  • Mice
  • Interferon-gamma
  • Herpesvirus 2, Human
  • Herpes Genitalis
  • Glycoproteins
  • Female