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An updated overview on Wnt signaling pathways: a prelude for more.

Publication ,  Journal Article
Rao, TP; Kühl, M
Published in: Circ Res
June 25, 2010

Growth factor signaling is required for cellular differentiation, tissue morphogenesis, and tissue homeostasis. Misregulation of intracellular signal transduction can lead to developmental defects during embryogenesis or particular diseases in the adult. One family of growth factors important for these aspects is given by the Wnt proteins. In particular, Wnts have important functions in stem cell biology, cardiac development and differentiation, angiogenesis, cardiac hypertrophy, cardiac failure, and aging. Knowledge of growth factor signaling during differentiation will allow for improvement of targeted differentiation of embryonic or adult stem cells toward functional cardiomyocytes or for understanding the basis of diseases. Our major aim here is to provide a state of the art review summarizing our present knowledge of the intracellular Wnt-mediated signaling network. In particular, we provide evidence that the subdivision into canonical and noncanonical Wnt signaling pathways solely based on the identity of Wnt ligands or Frizzled receptors is not appropriate anymore. We thereby deliver a solid base for further upcoming articles of a review series focusing on the role of Wnt proteins on different aspects of cardiovascular development and dysfunction.

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Published In

Circ Res

DOI

EISSN

1524-4571

Publication Date

June 25, 2010

Volume

106

Issue

12

Start / End Page

1798 / 1806

Location

United States

Related Subject Headings

  • beta Catenin
  • Wnt Proteins
  • Signal Transduction
  • Humans
  • Frizzled Receptors
  • Cell Membrane
  • Cardiovascular System & Hematology
  • Cardiovascular System
  • Animals
  • 3202 Clinical sciences
 

Citation

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Rao, T. P., & Kühl, M. (2010). An updated overview on Wnt signaling pathways: a prelude for more. Circ Res, 106(12), 1798–1806. https://doi.org/10.1161/CIRCRESAHA.110.219840
Rao, Tata Purushothama, and Michael Kühl. “An updated overview on Wnt signaling pathways: a prelude for more.Circ Res 106, no. 12 (June 25, 2010): 1798–1806. https://doi.org/10.1161/CIRCRESAHA.110.219840.
Rao TP, Kühl M. An updated overview on Wnt signaling pathways: a prelude for more. Circ Res. 2010 Jun 25;106(12):1798–806.
Rao, Tata Purushothama, and Michael Kühl. “An updated overview on Wnt signaling pathways: a prelude for more.Circ Res, vol. 106, no. 12, June 2010, pp. 1798–806. Pubmed, doi:10.1161/CIRCRESAHA.110.219840.
Rao TP, Kühl M. An updated overview on Wnt signaling pathways: a prelude for more. Circ Res. 2010 Jun 25;106(12):1798–1806.

Published In

Circ Res

DOI

EISSN

1524-4571

Publication Date

June 25, 2010

Volume

106

Issue

12

Start / End Page

1798 / 1806

Location

United States

Related Subject Headings

  • beta Catenin
  • Wnt Proteins
  • Signal Transduction
  • Humans
  • Frizzled Receptors
  • Cell Membrane
  • Cardiovascular System & Hematology
  • Cardiovascular System
  • Animals
  • 3202 Clinical sciences