TGFΒ-induced transcription in cancer.
Publication
, Journal Article
Cantelli, G; Crosas-Molist, E; Georgouli, M; Sanz-Moreno, V
Published in: Seminars in cancer biology
February 2017
The Transforming Growth Factor-beta (TGFβ) pathway mediates a broad spectrum of cellular processes and is involved in several diseases, including cancer. TGFβ has a dual role in tumours, acting as a tumour suppressor in the early phase of tumorigenesis and as a tumour promoter in more advanced stages. In this review, we discuss the effects of TGFβ-driven transcription on all stages of tumour progression, with special focus on lung cancer. Since some TGFβ target genes are specifically involved in promoting metastasis, we speculate that these genes might be good targets to block tumour progression without compromising the tumour suppressor effects of the TGFβ pathway.
Published In
Seminars in cancer biology
DOI
EISSN
1096-3650
ISSN
1044-579X
Publication Date
February 2017
Volume
42
Start / End Page
60 / 69
Related Subject Headings
- Transforming Growth Factor beta
- Transcription, Genetic
- Signal Transduction
- Oncology & Carcinogenesis
- Neoplasms
- Neoplasm Staging
- Humans
- Genes, Tumor Suppressor
- Cell Transformation, Neoplastic
- 3211 Oncology and carcinogenesis
Citation
APA
Chicago
ICMJE
MLA
NLM
Cantelli, G., Crosas-Molist, E., Georgouli, M., & Sanz-Moreno, V. (2017). TGFΒ-induced transcription in cancer. Seminars in Cancer Biology, 42, 60–69. https://doi.org/10.1016/j.semcancer.2016.08.009
Cantelli, Gaia, Eva Crosas-Molist, Mirella Georgouli, and Victoria Sanz-Moreno. “TGFΒ-induced transcription in cancer.” Seminars in Cancer Biology 42 (February 2017): 60–69. https://doi.org/10.1016/j.semcancer.2016.08.009.
Cantelli G, Crosas-Molist E, Georgouli M, Sanz-Moreno V. TGFΒ-induced transcription in cancer. Seminars in cancer biology. 2017 Feb;42:60–9.
Cantelli, Gaia, et al. “TGFΒ-induced transcription in cancer.” Seminars in Cancer Biology, vol. 42, Feb. 2017, pp. 60–69. Epmc, doi:10.1016/j.semcancer.2016.08.009.
Cantelli G, Crosas-Molist E, Georgouli M, Sanz-Moreno V. TGFΒ-induced transcription in cancer. Seminars in cancer biology. 2017 Feb;42:60–69.
Published In
Seminars in cancer biology
DOI
EISSN
1096-3650
ISSN
1044-579X
Publication Date
February 2017
Volume
42
Start / End Page
60 / 69
Related Subject Headings
- Transforming Growth Factor beta
- Transcription, Genetic
- Signal Transduction
- Oncology & Carcinogenesis
- Neoplasms
- Neoplasm Staging
- Humans
- Genes, Tumor Suppressor
- Cell Transformation, Neoplastic
- 3211 Oncology and carcinogenesis