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A region of interstitial 17q25 allelic loss in ovarian tumors coincides with a defined region of loss in breast tumors.

Publication ,  Journal Article
Kalikin, LM; Frank, TS; Svoboda-Newman, SM; Wetzel, JC; Cooney, KA; Petty, EM
Published in: Oncogene
April 24, 1997

Chromosomal regions of allelic imbalance in tumors are predicted to define the general location of tumor suppressor genes. We previously localized a putative breast tumor suppressor gene to a 3 cM region on 17q25 by deletion mapping of microsatellite markers in breast tumors. To determine if the same 17q25 region of loss is important in the genesis of other tumor types, 32 ovarian tumors and 24 prostate tumors, as well as 33 additional breast tumors, were analysed with 17q25 polymorphic microsatellite markers. While no significant loss was observed in prostate tumors, greater than half of ovarian tumors exhibited loss coincident with the candidate region previously defined in breast tumors. These results suggest that one or more novel tumor suppressor genes exist on 17q25 within a concordant region of interstitial loss defined in both breast and ovarian neoplasms.

Duke Scholars

Published In

Oncogene

DOI

ISSN

0950-9232

Publication Date

April 24, 1997

Volume

14

Issue

16

Start / End Page

1991 / 1994

Location

England

Related Subject Headings

  • Prostatic Neoplasms
  • Polymorphism, Genetic
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Microsatellite Repeats
  • Male
  • Humans
  • Genetic Markers
  • Gene Deletion
  • Female
 

Citation

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Kalikin, L. M., Frank, T. S., Svoboda-Newman, S. M., Wetzel, J. C., Cooney, K. A., & Petty, E. M. (1997). A region of interstitial 17q25 allelic loss in ovarian tumors coincides with a defined region of loss in breast tumors. Oncogene, 14(16), 1991–1994. https://doi.org/10.1038/sj.onc.1201013
Kalikin, L. M., T. S. Frank, S. M. Svoboda-Newman, J. C. Wetzel, K. A. Cooney, and E. M. Petty. “A region of interstitial 17q25 allelic loss in ovarian tumors coincides with a defined region of loss in breast tumors.Oncogene 14, no. 16 (April 24, 1997): 1991–94. https://doi.org/10.1038/sj.onc.1201013.
Kalikin LM, Frank TS, Svoboda-Newman SM, Wetzel JC, Cooney KA, Petty EM. A region of interstitial 17q25 allelic loss in ovarian tumors coincides with a defined region of loss in breast tumors. Oncogene. 1997 Apr 24;14(16):1991–4.
Kalikin, L. M., et al. “A region of interstitial 17q25 allelic loss in ovarian tumors coincides with a defined region of loss in breast tumors.Oncogene, vol. 14, no. 16, Apr. 1997, pp. 1991–94. Pubmed, doi:10.1038/sj.onc.1201013.
Kalikin LM, Frank TS, Svoboda-Newman SM, Wetzel JC, Cooney KA, Petty EM. A region of interstitial 17q25 allelic loss in ovarian tumors coincides with a defined region of loss in breast tumors. Oncogene. 1997 Apr 24;14(16):1991–1994.

Published In

Oncogene

DOI

ISSN

0950-9232

Publication Date

April 24, 1997

Volume

14

Issue

16

Start / End Page

1991 / 1994

Location

England

Related Subject Headings

  • Prostatic Neoplasms
  • Polymorphism, Genetic
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Microsatellite Repeats
  • Male
  • Humans
  • Genetic Markers
  • Gene Deletion
  • Female