Skip to main content
Journal cover image

Evidence for an association between prostate cancer and chromosome 8q24 and 10q11 genetic variants in African American men: the Flint Men's Health Study.

Publication ,  Journal Article
Wang, Y; Ray, AM; Johnson, EK; Zuhlke, KA; Cooney, KA; Lange, EM
Published in: Prostate
February 15, 2011

BACKGROUND: Prostate cancer is the most commonly diagnosed non-skin cancer in men in the United States and the second leading cause of cancer-related mortality. African American men have substantially increased risk of both being diagnosed and dying from the disease. Recent genome-wide genetic association studies have identified a number of common single nucleotide genetic polymorphisms (SNPs) that are associated with prostate cancer in men of European descent. Only a small number of studies have evaluated the association between these genetic variants and prostate cancer in African Americans. METHODS: We used logistic regression models to assess the association between prostate cancer in African American men and 24 SNPs from regions previously reported to be associated with prostate cancer in men of European descent. RESULTS: We found nominal evidence (P < 0.05) for association between prostate cancer and three chromosome 8q24 (rs6983561, rs16901979, and rs7000448) and two 10q11 (rs7904463 and rs10740051) SNPs. CONCLUSIONS: We confirm recent reports that 8q24 variants identified to be associated with prostate cancer in men of European descent are also associated with prostate cancer in African Americans. Our report is the first to find evidence of association between SNPs near MSMB and prostate cancer in African Americans. Of note, rs7000448 is in strong linkage disequilibrium with rs10761581 in NCOA4, a SNP that has been implicated to be independently associated, with respect to the widely reported SNP rs10993994 in the nearby gene MSMB, with prostate cancer in men of European descent.

Duke Scholars

Published In

Prostate

DOI

EISSN

1097-0045

Publication Date

February 15, 2011

Volume

71

Issue

3

Start / End Page

225 / 231

Location

United States

Related Subject Headings

  • Prostatic Neoplasms
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Logistic Models
  • Linkage Disequilibrium
  • Humans
  • Chromosomes, Human, Pair 8
  • Chromosomes, Human, Pair 10
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wang, Y., Ray, A. M., Johnson, E. K., Zuhlke, K. A., Cooney, K. A., & Lange, E. M. (2011). Evidence for an association between prostate cancer and chromosome 8q24 and 10q11 genetic variants in African American men: the Flint Men's Health Study. Prostate, 71(3), 225–231. https://doi.org/10.1002/pros.21234
Wang, Yunfei, Anna M. Ray, Emilie K. Johnson, Kimberly A. Zuhlke, Kathleen A. Cooney, and Ethan M. Lange. “Evidence for an association between prostate cancer and chromosome 8q24 and 10q11 genetic variants in African American men: the Flint Men's Health Study.Prostate 71, no. 3 (February 15, 2011): 225–31. https://doi.org/10.1002/pros.21234.
Wang, Yunfei, et al. “Evidence for an association between prostate cancer and chromosome 8q24 and 10q11 genetic variants in African American men: the Flint Men's Health Study.Prostate, vol. 71, no. 3, Feb. 2011, pp. 225–31. Pubmed, doi:10.1002/pros.21234.
Journal cover image

Published In

Prostate

DOI

EISSN

1097-0045

Publication Date

February 15, 2011

Volume

71

Issue

3

Start / End Page

225 / 231

Location

United States

Related Subject Headings

  • Prostatic Neoplasms
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Logistic Models
  • Linkage Disequilibrium
  • Humans
  • Chromosomes, Human, Pair 8
  • Chromosomes, Human, Pair 10