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Genome-wide linkage scan for prostate cancer aggressiveness loci using families from the University of Michigan Prostate Cancer Genetics Project.

Publication ,  Journal Article
Slager, SL; Zarfas, KE; Brown, WM; Lange, EM; McDonnell, SK; Wojno, KJ; Cooney, KA
Published in: Prostate
February 1, 2006

BACKGROUND: Prostate cancer (PC) is a complex disease that displays variable disease outcome, ranging from a relatively indolent disease to forms that result in death from the disease. One measure of disease severity is the Gleason score. Using the Gleason score as a measure of tumor aggressiveness, several independent genome scans have reported evidence of linkage. As of yet, however, no genes have been implicated. METHODS: We report an independent genome scan using the Gleason score as a quantitative trait. We genotyped 405 highly polymorphic microsatellite markers in 175 brother pairs from 103 families. RESULTS: Our strongest evidence of linkage is to 6q23 at 137 cM (D6S292, P = 0.0009). Other interesting regions (P < 0.005) were on chromosome 1p13-q21 and on chromosome 5p13-q11. CONCLUSIONS: Our results provide further evidence that tumor aggressiveness has a genetic component, and that this genetic component may be influenced by several independent genes.

Duke Scholars

Published In

Prostate

DOI

ISSN

0270-4137

Publication Date

February 1, 2006

Volume

66

Issue

2

Start / End Page

173 / 179

Location

United States

Related Subject Headings

  • White People
  • Severity of Illness Index
  • Quantitative Trait, Heritable
  • Prostatic Neoplasms
  • Pedigree
  • Oncology & Carcinogenesis
  • Neoplasm Invasiveness
  • Middle Aged
  • Microsatellite Repeats
  • Male
 

Citation

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MLA
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Slager, S. L., Zarfas, K. E., Brown, W. M., Lange, E. M., McDonnell, S. K., Wojno, K. J., & Cooney, K. A. (2006). Genome-wide linkage scan for prostate cancer aggressiveness loci using families from the University of Michigan Prostate Cancer Genetics Project. Prostate, 66(2), 173–179. https://doi.org/10.1002/pros.20332
Slager, Susan L., Katherine E. Zarfas, W Mark Brown, Ethan M. Lange, Shannon K. McDonnell, Kirk J. Wojno, and Kathleen A. Cooney. “Genome-wide linkage scan for prostate cancer aggressiveness loci using families from the University of Michigan Prostate Cancer Genetics Project.Prostate 66, no. 2 (February 1, 2006): 173–79. https://doi.org/10.1002/pros.20332.
Slager SL, Zarfas KE, Brown WM, Lange EM, McDonnell SK, Wojno KJ, et al. Genome-wide linkage scan for prostate cancer aggressiveness loci using families from the University of Michigan Prostate Cancer Genetics Project. Prostate. 2006 Feb 1;66(2):173–9.
Slager, Susan L., et al. “Genome-wide linkage scan for prostate cancer aggressiveness loci using families from the University of Michigan Prostate Cancer Genetics Project.Prostate, vol. 66, no. 2, Feb. 2006, pp. 173–79. Pubmed, doi:10.1002/pros.20332.
Slager SL, Zarfas KE, Brown WM, Lange EM, McDonnell SK, Wojno KJ, Cooney KA. Genome-wide linkage scan for prostate cancer aggressiveness loci using families from the University of Michigan Prostate Cancer Genetics Project. Prostate. 2006 Feb 1;66(2):173–179.
Journal cover image

Published In

Prostate

DOI

ISSN

0270-4137

Publication Date

February 1, 2006

Volume

66

Issue

2

Start / End Page

173 / 179

Location

United States

Related Subject Headings

  • White People
  • Severity of Illness Index
  • Quantitative Trait, Heritable
  • Prostatic Neoplasms
  • Pedigree
  • Oncology & Carcinogenesis
  • Neoplasm Invasiveness
  • Middle Aged
  • Microsatellite Repeats
  • Male