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A common variant associated with prostate cancer in European and African populations.

Publication ,  Journal Article
Amundadottir, LT; Sulem, P; Gudmundsson, J; Helgason, A; Baker, A; Agnarsson, BA; Sigurdsson, A; Benediktsdottir, KR; Cazier, J-B; Sainz, J ...
Published in: Nat Genet
June 2006

With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele -8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US. The estimated odds ratio (OR) of the allele is 1.62 (P = 2.7 x 10(-11)). About 19% of affected men and 13% of the general population carry at least one copy, yielding a population attributable risk (PAR) of approximately 8%. The association was also replicated in an African American case-control group with a similar OR, in which 41% of affected individuals and 30% of the population are carriers. This leads to a greater estimated PAR (16%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry.

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Published In

Nat Genet

DOI

ISSN

1061-4036

Publication Date

June 2006

Volume

38

Issue

6

Start / End Page

652 / 658

Location

United States

Related Subject Headings

  • White People
  • Prostatic Neoplasms
  • Polymorphism, Single Nucleotide
  • Microsatellite Repeats
  • Male
  • Humans
  • Developmental Biology
  • Black People
  • Alleles
  • 3105 Genetics
 

Citation

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Amundadottir, L. T., Sulem, P., Gudmundsson, J., Helgason, A., Baker, A., Agnarsson, B. A., … Stefansson, K. (2006). A common variant associated with prostate cancer in European and African populations. Nat Genet, 38(6), 652–658. https://doi.org/10.1038/ng1808
Amundadottir, Laufey T., Patrick Sulem, Julius Gudmundsson, Agnar Helgason, Adam Baker, Bjarni A. Agnarsson, Asgeir Sigurdsson, et al. “A common variant associated with prostate cancer in European and African populations.Nat Genet 38, no. 6 (June 2006): 652–58. https://doi.org/10.1038/ng1808.
Amundadottir LT, Sulem P, Gudmundsson J, Helgason A, Baker A, Agnarsson BA, et al. A common variant associated with prostate cancer in European and African populations. Nat Genet. 2006 Jun;38(6):652–8.
Amundadottir, Laufey T., et al. “A common variant associated with prostate cancer in European and African populations.Nat Genet, vol. 38, no. 6, June 2006, pp. 652–58. Pubmed, doi:10.1038/ng1808.
Amundadottir LT, Sulem P, Gudmundsson J, Helgason A, Baker A, Agnarsson BA, Sigurdsson A, Benediktsdottir KR, Cazier J-B, Sainz J, Jakobsdottir M, Kostic J, Magnusdottir DN, Ghosh S, Agnarsson K, Birgisdottir B, Le Roux L, Olafsdottir A, Blondal T, Andresdottir M, Gretarsdottir OS, Bergthorsson JT, Gudbjartsson D, Gylfason A, Thorleifsson G, Manolescu A, Kristjansson K, Geirsson G, Isaksson H, Douglas J, Johansson J-E, Bälter K, Wiklund F, Montie JE, Yu X, Suarez BK, Ober C, Cooney KA, Gronberg H, Catalona WJ, Einarsson GV, Barkardottir RB, Gulcher JR, Kong A, Thorsteinsdottir U, Stefansson K. A common variant associated with prostate cancer in European and African populations. Nat Genet. 2006 Jun;38(6):652–658.

Published In

Nat Genet

DOI

ISSN

1061-4036

Publication Date

June 2006

Volume

38

Issue

6

Start / End Page

652 / 658

Location

United States

Related Subject Headings

  • White People
  • Prostatic Neoplasms
  • Polymorphism, Single Nucleotide
  • Microsatellite Repeats
  • Male
  • Humans
  • Developmental Biology
  • Black People
  • Alleles
  • 3105 Genetics