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Insulin-like growth factor-1, insulin-like growth factor binding protein-3, and body mass index: clinical correlates of prostate volume among Black men.

Publication ,  Journal Article
Sarma, AV; Jaffe, CA; Schottenfeld, D; Dunn, R; Montie, JE; Cooney, KA; Wei, JT
Published in: Urology
March 2002

OBJECTIVES: To examine the relationship between insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3), and body mass index and prostate volume, as a surrogate marker for benign prostatic hyperplasia, in a community-based sample of black men. Epidemiologic studies examining the role of IGF-1 and IGFBP-3 suggest that increased levels of serum IGF-1 and decreased levels of serum IGFBP-3 are associated with an increased risk of prostate cancer. Few studies have examined these factors with respect to benign prostatic hyperplasia, and these have been limited to white men. METHODS: The study population consisted of a sample of 364 black men, 40 to 79 years of age, residing in Genesee County, Michigan. Men with prostate cancer or prior prostate surgery were excluded. All subjects completed a clinical examination, which included a complete urologic examination with transrectal ultrasonography, anthropometric measurements, and serum assays for IGF-1 and IGFBP-3. RESULTS: Multivariable regression models demonstrated that prostate volume increased with increasing age (P <0.0001) and body mass index (P = 0.03). IGFBP-3 rather than IGF-1 was positively associated with increasing prostate volume (P = 0.003). CONCLUSIONS: This is the largest study describing the relationships between IGF-1, IGFBP-3, and body mass index and prostate volume, and the only study in black men. Although earlier studies demonstrated an association between IGF-1 and prostate cancer risk, our findings indicate that IGFBP-3 is more relevant for prostate enlargement, suggesting that IGF-1 and IGFBP-3 may play different pathophysiologic roles in benign and malignant prostatic conditions.

Duke Scholars

Published In

Urology

DOI

EISSN

1527-9995

Publication Date

March 2002

Volume

59

Issue

3

Start / End Page

362 / 367

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Ultrasonography
  • Prostatic Hyperplasia
  • Prostate
  • Multivariate Analysis
  • Middle Aged
  • Male
  • Linear Models
  • Insulin-Like Growth Factor I
  • Insulin-Like Growth Factor Binding Protein 3
 

Citation

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ICMJE
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Sarma, A. V., Jaffe, C. A., Schottenfeld, D., Dunn, R., Montie, J. E., Cooney, K. A., & Wei, J. T. (2002). Insulin-like growth factor-1, insulin-like growth factor binding protein-3, and body mass index: clinical correlates of prostate volume among Black men. Urology, 59(3), 362–367. https://doi.org/10.1016/s0090-4295(01)01546-1
Sarma, Aruna V., Craig A. Jaffe, David Schottenfeld, Rodney Dunn, James E. Montie, Kathleen A. Cooney, and John T. Wei. “Insulin-like growth factor-1, insulin-like growth factor binding protein-3, and body mass index: clinical correlates of prostate volume among Black men.Urology 59, no. 3 (March 2002): 362–67. https://doi.org/10.1016/s0090-4295(01)01546-1.
Sarma AV, Jaffe CA, Schottenfeld D, Dunn R, Montie JE, Cooney KA, et al. Insulin-like growth factor-1, insulin-like growth factor binding protein-3, and body mass index: clinical correlates of prostate volume among Black men. Urology. 2002 Mar;59(3):362–7.
Sarma, Aruna V., et al. “Insulin-like growth factor-1, insulin-like growth factor binding protein-3, and body mass index: clinical correlates of prostate volume among Black men.Urology, vol. 59, no. 3, Mar. 2002, pp. 362–67. Pubmed, doi:10.1016/s0090-4295(01)01546-1.
Sarma AV, Jaffe CA, Schottenfeld D, Dunn R, Montie JE, Cooney KA, Wei JT. Insulin-like growth factor-1, insulin-like growth factor binding protein-3, and body mass index: clinical correlates of prostate volume among Black men. Urology. 2002 Mar;59(3):362–367.
Journal cover image

Published In

Urology

DOI

EISSN

1527-9995

Publication Date

March 2002

Volume

59

Issue

3

Start / End Page

362 / 367

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Ultrasonography
  • Prostatic Hyperplasia
  • Prostate
  • Multivariate Analysis
  • Middle Aged
  • Male
  • Linear Models
  • Insulin-Like Growth Factor I
  • Insulin-Like Growth Factor Binding Protein 3