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Association between Agent Orange and prostate cancer: a pilot case-control study.

Publication ,  Journal Article
Giri, VN; Cassidy, AE; Beebe-Dimmer, J; Ellis, LR; Smith, DC; Bock, CH; Cooney, KA
Published in: Urology
April 2004

OBJECTIVES: To estimate in a pilot study the risk of being diagnosed with prostate cancer after exposure to Agent Orange in a clinical population of military veterans. Prostate cancer is the most common cancer diagnosed in American men and the second leading cause of cancer deaths. An association between Agent Orange and prostate cancer has been suggested by epidemiologic studies. METHODS: A case-control study was conducted at the Department of Veterans Affairs Medical Center in Ann Arbor, Michigan. Cases of pathologically diagnosed prostate cancer were identified and age matched in a 1:3 ratio with controls. Exposure to Agent Orange was assessed by reviewing the administrative portion of the computerized medical records. A subanalysis of the cases was conducted to examine the clinical features of prostate cancer in men reporting exposure to Agent Orange versus those who did not report exposure. RESULTS: A total of 47 military veterans with prostate cancer and 142 control men without prostate cancer were selected. After adjusting for age and race, men with prostate cancer were approximately two times more likely to report previous exposure to Agent Orange (odds ratio 2.06; 95% confidence interval 0.81 to 5.23). CONCLUSIONS: The results from this pilot study suggest exposure to Agent Orange is associated with an increased risk of prostate cancer. Additional study in larger populations is necessary to confirm and to quantify this association more accurately.

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Published In

Urology

DOI

EISSN

1527-9995

Publication Date

April 2004

Volume

63

Issue

4

Start / End Page

757 / 760

Location

United States

Related Subject Headings

  • Warfare
  • Vietnam
  • Veterans
  • Urology & Nephrology
  • Risk Factors
  • Prostatic Neoplasms
  • Prostate
  • Polychlorinated Dibenzodioxins
  • Pilot Projects
  • Middle Aged
 

Citation

APA
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ICMJE
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Giri, V. N., Cassidy, A. E., Beebe-Dimmer, J., Ellis, L. R., Smith, D. C., Bock, C. H., & Cooney, K. A. (2004). Association between Agent Orange and prostate cancer: a pilot case-control study. Urology, 63(4), 757–760. https://doi.org/10.1016/j.urology.2003.11.044
Giri, Veda Nargund, Andrea E. Cassidy, Jennifer Beebe-Dimmer, Leslie R. Ellis, David C. Smith, Cathryn H. Bock, and Kathleen A. Cooney. “Association between Agent Orange and prostate cancer: a pilot case-control study.Urology 63, no. 4 (April 2004): 757–60. https://doi.org/10.1016/j.urology.2003.11.044.
Giri VN, Cassidy AE, Beebe-Dimmer J, Ellis LR, Smith DC, Bock CH, et al. Association between Agent Orange and prostate cancer: a pilot case-control study. Urology. 2004 Apr;63(4):757–60.
Giri, Veda Nargund, et al. “Association between Agent Orange and prostate cancer: a pilot case-control study.Urology, vol. 63, no. 4, Apr. 2004, pp. 757–60. Pubmed, doi:10.1016/j.urology.2003.11.044.
Giri VN, Cassidy AE, Beebe-Dimmer J, Ellis LR, Smith DC, Bock CH, Cooney KA. Association between Agent Orange and prostate cancer: a pilot case-control study. Urology. 2004 Apr;63(4):757–760.
Journal cover image

Published In

Urology

DOI

EISSN

1527-9995

Publication Date

April 2004

Volume

63

Issue

4

Start / End Page

757 / 760

Location

United States

Related Subject Headings

  • Warfare
  • Vietnam
  • Veterans
  • Urology & Nephrology
  • Risk Factors
  • Prostatic Neoplasms
  • Prostate
  • Polychlorinated Dibenzodioxins
  • Pilot Projects
  • Middle Aged