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Current views on collapsing glomerulopathy.

Publication ,  Journal Article
Albaqumi, M; Barisoni, L
Published in: J Am Soc Nephrol
July 2008

Collapsing glomerulopathy is a proliferative disease defined by segmental or global wrinkling of the glomerular basement membranes associated with podocyte proliferation. These lesions are particularly poor responders to standard therapies. First described as an idiopathic disorder or following HIV infection, it is now associated with a broad group of diseases and different pathogenetic mechanisms, which participate in podocyte injury and mitogenic stimulation. Because of this etiologic heterogeneity, there is clear need for new therapeutic approaches to target each variant of this entity. Historical background, terminology, morphologic and phenotypic features, and suggested mechanisms are reviewed in this manuscript.

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Published In

J Am Soc Nephrol

DOI

EISSN

1533-3450

Publication Date

July 2008

Volume

19

Issue

7

Start / End Page

1276 / 1281

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Phenotype
  • Kidney Glomerulus
  • Humans
  • Glomerulosclerosis, Focal Segmental
  • Female
  • Adult
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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Chicago
ICMJE
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Albaqumi, M., & Barisoni, L. (2008). Current views on collapsing glomerulopathy. J Am Soc Nephrol, 19(7), 1276–1281. https://doi.org/10.1681/ASN.2007080926
Albaqumi, Mamdouh, and Laura Barisoni. “Current views on collapsing glomerulopathy.J Am Soc Nephrol 19, no. 7 (July 2008): 1276–81. https://doi.org/10.1681/ASN.2007080926.
Albaqumi M, Barisoni L. Current views on collapsing glomerulopathy. J Am Soc Nephrol. 2008 Jul;19(7):1276–81.
Albaqumi, Mamdouh, and Laura Barisoni. “Current views on collapsing glomerulopathy.J Am Soc Nephrol, vol. 19, no. 7, July 2008, pp. 1276–81. Pubmed, doi:10.1681/ASN.2007080926.
Albaqumi M, Barisoni L. Current views on collapsing glomerulopathy. J Am Soc Nephrol. 2008 Jul;19(7):1276–1281.

Published In

J Am Soc Nephrol

DOI

EISSN

1533-3450

Publication Date

July 2008

Volume

19

Issue

7

Start / End Page

1276 / 1281

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Phenotype
  • Kidney Glomerulus
  • Humans
  • Glomerulosclerosis, Focal Segmental
  • Female
  • Adult
  • 3202 Clinical sciences
  • 1103 Clinical Sciences