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Management guidelines for paediatric patients receiving chimeric antigen receptor T cell therapy.

Publication ,  Journal Article
Mahadeo, KM; Khazal, SJ; Abdel-Azim, H; Fitzgerald, JC; Taraseviciute, A; Bollard, CM; Tewari, P; Duncan, C; Traube, C; McCall, D; Steiner, ME ...
Published in: Nat Rev Clin Oncol
January 2019
Published version (DOI) Link to item

In 2017, an autologous chimeric antigen receptor (CAR) T cell therapy indicated for children and young adults with relapsed and/or refractory CD19+ acute lymphoblastic leukaemia became the first gene therapy to be approved in the USA. This innovative form of cellular immunotherapy has been associated with remarkable response rates but is also associated with unique and often severe toxicities, which can lead to rapid cardiorespiratory and/or neurological deterioration. Multidisciplinary medical vigilance and the requisite health-care infrastructure are imperative to ensuring optimal patient outcomes, especially as these therapies transition from research protocols to standard care. Herein, authors representing the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network Hematopoietic Stem Cell Transplantation (HSCT) Subgroup and the MD Anderson Cancer Center CAR T Cell Therapy-Associated Toxicity (CARTOX) Program have collaborated to provide comprehensive consensus guidelines on the care of children receiving CAR T cell therapy.

Duke Scholars

Kris Mahadeo
Author Kris Mahadeo Pediatrics, Transplant and Cellular Therapy
Paul Langlie Martin
Author Paul Langlie Martin Pediatrics, Transplant and Cellular Therapy
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Published In

Nat Rev Clin Oncol

DOI

10.1038/s41571-018-0075-2

EISSN

1759-4782

Publication Date

January 2019

Volume

16

Issue

1

Start / End Page

45 / 63

Location

England

Related Subject Headings

  • Young Adult
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Practice Guidelines as Topic
  • Immunotherapy, Adoptive
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Child
  • Acute Lung Injury
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

APA
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Mahadeo, K. M., Khazal, S. J., Abdel-Azim, H., Fitzgerald, J. C., Taraseviciute, A., Bollard, C. M., … Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, . (2019). Management guidelines for paediatric patients receiving chimeric antigen receptor T cell therapy. Nat Rev Clin Oncol, 16(1), 45–63. https://doi.org/10.1038/s41571-018-0075-2
Mahadeo, Kris M., Sajad J. Khazal, Hisham Abdel-Azim, Julie C. Fitzgerald, Agne Taraseviciute, Catherine M. Bollard, Priti Tewari, et al. “Management guidelines for paediatric patients receiving chimeric antigen receptor T cell therapy.” Nat Rev Clin Oncol 16, no. 1 (January 2019): 45–63. https://doi.org/10.1038/s41571-018-0075-2.
Mahadeo KM, Khazal SJ, Abdel-Azim H, Fitzgerald JC, Taraseviciute A, Bollard CM, et al. Management guidelines for paediatric patients receiving chimeric antigen receptor T cell therapy. Nat Rev Clin Oncol. 2019 Jan;16(1):45–63.
Mahadeo, Kris M., et al. “Management guidelines for paediatric patients receiving chimeric antigen receptor T cell therapy.” Nat Rev Clin Oncol, vol. 16, no. 1, Jan. 2019, pp. 45–63. Pubmed, doi:10.1038/s41571-018-0075-2.
Mahadeo KM, Khazal SJ, Abdel-Azim H, Fitzgerald JC, Taraseviciute A, Bollard CM, Tewari P, Duncan C, Traube C, McCall D, Steiner ME, Cheifetz IM, Lehmann LE, Mejia R, Slopis JM, Bajwa R, Kebriaei P, Martin PL, Moffet J, McArthur J, Petropoulos D, O’Hanlon Curry J, Featherston S, Foglesong J, Shoberu B, Gulbis A, Mireles ME, Hafemeister L, Nguyen C, Kapoor N, Rezvani K, Neelapu SS, Shpall EJ, Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Management guidelines for paediatric patients receiving chimeric antigen receptor T cell therapy. Nat Rev Clin Oncol. 2019 Jan;16(1):45–63.

Published In

Nat Rev Clin Oncol

DOI

10.1038/s41571-018-0075-2

EISSN

1759-4782

Publication Date

January 2019

Volume

16

Issue

1

Start / End Page

45 / 63

Location

England

Related Subject Headings

  • Young Adult
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Practice Guidelines as Topic
  • Immunotherapy, Adoptive
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Child
  • Acute Lung Injury
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis