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Interaction of GLP-1 and Ghrelin on Glucose Tolerance in Healthy Humans.

Publication ,  Journal Article
Page, LC; Gastaldelli, A; Gray, SM; D'Alessio, DA; Tong, J
Published in: Diabetes
October 2018

Emerging evidence supports the importance of ghrelin to defend against starvation-induced hypoglycemia. This effect may be mediated by inhibition of glucose-stimulated insulin secretion as well as reduced insulin sensitivity. However, administration of ghrelin during meal consumption also stimulates the release of glucagon-like peptide 1 (GLP-1), an incretin important in nutrient disposition. The objective of this study was to evaluate the interaction between ghrelin and GLP-1 on parameters of glucose tolerance following a mixed-nutrient meal. Fifteen healthy men and women completed the study. Each consumed a standard meal on four separate occasions with a superimposed infusion of 1) saline, 2) ghrelin, 3) the GLP-1 receptor antagonist exendin(9-39) (Ex9), or 4) combined ghrelin and Ex9. Similar to previous studies, infusion of ghrelin caused glucose intolerance, whereas Ex9 had a minimal effect. However, combined ghrelin and Ex9 resulted in greater postprandial glycemia than either alone, and this effect was associated with impaired β-cell function and decreased glucose clearance. These findings suggest that in the fed state, stimulation of GLP-1 mitigates some of the effect of ghrelin on glucose tolerance. This novel interaction between gastrointestinal hormones suggests a system that balances insulin secretion and glucose disposal in the fed and fasting states.

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Published In

Diabetes

DOI

EISSN

1939-327X

Publication Date

October 2018

Volume

67

Issue

10

Start / End Page

1976 / 1985

Location

United States

Related Subject Headings

  • Young Adult
  • Postprandial Period
  • Male
  • Insulin
  • Humans
  • Glucose Intolerance
  • Glucose
  • Glucagon-Like Peptide-1 Receptor
  • Glucagon-Like Peptide 1
  • Ghrelin
 

Citation

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Page, L. C., Gastaldelli, A., Gray, S. M., D’Alessio, D. A., & Tong, J. (2018). Interaction of GLP-1 and Ghrelin on Glucose Tolerance in Healthy Humans. Diabetes, 67(10), 1976–1985. https://doi.org/10.2337/db18-0451
Page, Laura C., Amalia Gastaldelli, Sarah M. Gray, David A. D’Alessio, and Jenny Tong. “Interaction of GLP-1 and Ghrelin on Glucose Tolerance in Healthy Humans.Diabetes 67, no. 10 (October 2018): 1976–85. https://doi.org/10.2337/db18-0451.
Page LC, Gastaldelli A, Gray SM, D’Alessio DA, Tong J. Interaction of GLP-1 and Ghrelin on Glucose Tolerance in Healthy Humans. Diabetes. 2018 Oct;67(10):1976–85.
Page, Laura C., et al. “Interaction of GLP-1 and Ghrelin on Glucose Tolerance in Healthy Humans.Diabetes, vol. 67, no. 10, Oct. 2018, pp. 1976–85. Pubmed, doi:10.2337/db18-0451.
Page LC, Gastaldelli A, Gray SM, D’Alessio DA, Tong J. Interaction of GLP-1 and Ghrelin on Glucose Tolerance in Healthy Humans. Diabetes. 2018 Oct;67(10):1976–1985.

Published In

Diabetes

DOI

EISSN

1939-327X

Publication Date

October 2018

Volume

67

Issue

10

Start / End Page

1976 / 1985

Location

United States

Related Subject Headings

  • Young Adult
  • Postprandial Period
  • Male
  • Insulin
  • Humans
  • Glucose Intolerance
  • Glucose
  • Glucagon-Like Peptide-1 Receptor
  • Glucagon-Like Peptide 1
  • Ghrelin