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Serum biomarkers for diagnosis and monitoring viral hepatitis and hepatocellular carcinoma.

Publication ,  Journal Article
Kotha, S; Neong, S; Patel, K
Published in: Expert Rev Mol Diagn
August 2018

Chronic liver disease due to viral hepatitis continues to be a major global health concern. Timely diagnosis and treatment will prevent cirrhosis, risk of hepatocellular carcinoma (HCC), and requirement for liver transplantation. Numerous serum biomarkers are available for viral hepatitis that are helpful in diagnosis, measuring severity, progression of disease, evaluating the best therapeutic options, and monitoring antiviral treatment response. Determining the clinical use of available diagnostic tests can be challenging for the health care provider. Areas covered: This review article attempts to summarize the established and emerging serological markers for diagnosis and managing viral hepatitis. The literature search was performed in February 2018 and included MEDLINE and Embase databases for recent relevant literature on biomarkers for viral hepatitis. Expert Commentary: Despite the discovery of several candidate biomarkers, translating these to clinical practice in viral hepatitis and HCC remains challenging. While limited availability of the new biomarkers in prevalent geographic areas and significant cost remain major obstacles, there have been exciting developments in this field. Understanding the detection limits and sensitivity of these markers and translating them into clinical use is important in management of viral hepatitis and complications of liver disease such as cirrhosis and hepatocellular cancer.

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Published In

Expert Rev Mol Diagn

DOI

EISSN

1744-8352

Publication Date

August 2018

Volume

18

Issue

8

Start / End Page

713 / 722

Location

England

Related Subject Headings

  • Sensitivity and Specificity
  • Liver Neoplasms
  • Humans
  • Hepatitis C
  • Carcinoma, Hepatocellular
  • Biomarkers, Tumor
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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Kotha, S., Neong, S., & Patel, K. (2018). Serum biomarkers for diagnosis and monitoring viral hepatitis and hepatocellular carcinoma. Expert Rev Mol Diagn, 18(8), 713–722. https://doi.org/10.1080/14737159.2018.1496020
Kotha, Sreelakshmi, ShuetFong Neong, and Keyur Patel. “Serum biomarkers for diagnosis and monitoring viral hepatitis and hepatocellular carcinoma.Expert Rev Mol Diagn 18, no. 8 (August 2018): 713–22. https://doi.org/10.1080/14737159.2018.1496020.
Kotha S, Neong S, Patel K. Serum biomarkers for diagnosis and monitoring viral hepatitis and hepatocellular carcinoma. Expert Rev Mol Diagn. 2018 Aug;18(8):713–22.
Kotha, Sreelakshmi, et al. “Serum biomarkers for diagnosis and monitoring viral hepatitis and hepatocellular carcinoma.Expert Rev Mol Diagn, vol. 18, no. 8, Aug. 2018, pp. 713–22. Pubmed, doi:10.1080/14737159.2018.1496020.
Kotha S, Neong S, Patel K. Serum biomarkers for diagnosis and monitoring viral hepatitis and hepatocellular carcinoma. Expert Rev Mol Diagn. 2018 Aug;18(8):713–722.
Journal cover image

Published In

Expert Rev Mol Diagn

DOI

EISSN

1744-8352

Publication Date

August 2018

Volume

18

Issue

8

Start / End Page

713 / 722

Location

England

Related Subject Headings

  • Sensitivity and Specificity
  • Liver Neoplasms
  • Humans
  • Hepatitis C
  • Carcinoma, Hepatocellular
  • Biomarkers, Tumor
  • 3202 Clinical sciences
  • 1103 Clinical Sciences