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Skeletal muscle metastasis from signet ring cell esophageal adenocarcinoma

Publication ,  Journal Article
Ludmir, EB; Robey, B; Shelby, E; Patel-Nguyen, SV; Rittershaus, A; Contarino, MR
Published in: Translational Gastroenterology and Hepatology
January 1, 2016

Symptomatic skeletal muscle metastasis from esophageal adenocarcinoma is rare. Here we report the case of a 49-year-old man who presented with right thigh pain, and was found to have symptomatic psoas muscle metastasis as the presentation of esophageal adenocarcinoma. The primary tumor was notable for signet ring cells (SRC), a poor prognostic indicator as well as a predictor of biologic aggressiveness. The patient passed away within 1 month of diagnosis due to disease progression, supporting the aggressiveness of such SRC esophageal lesions. Lastly, a literature review reveals a differential pattern of metastatic spread between esophageal adenocarcinomas and squamous cell carcinomas as regards muscle metastases. Skeletal muscle metastases are more likely to be due to esophageal adenocarcinoma, whereas myocardial metastases are almost exclusively due to esophageal squamous cell carcinoma (ESCC). These differences may represent an example of the 'seed and soil' hypothesis of metastasis.

Duke Scholars

Published In

Translational Gastroenterology and Hepatology

DOI

EISSN

2224-4778

ISSN

2224-476X

Publication Date

January 1, 2016

Volume

2016

Issue

MAY

Related Subject Headings

  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ludmir, E. B., Robey, B., Shelby, E., Patel-Nguyen, S. V., Rittershaus, A., & Contarino, M. R. (2016). Skeletal muscle metastasis from signet ring cell esophageal adenocarcinoma. Translational Gastroenterology and Hepatology, 2016(MAY). https://doi.org/10.21037/tgh.2016.04.05
Ludmir, E. B., B. Robey, E. Shelby, S. V. Patel-Nguyen, A. Rittershaus, and M. R. Contarino. “Skeletal muscle metastasis from signet ring cell esophageal adenocarcinoma.” Translational Gastroenterology and Hepatology 2016, no. MAY (January 1, 2016). https://doi.org/10.21037/tgh.2016.04.05.
Ludmir EB, Robey B, Shelby E, Patel-Nguyen SV, Rittershaus A, Contarino MR. Skeletal muscle metastasis from signet ring cell esophageal adenocarcinoma. Translational Gastroenterology and Hepatology. 2016 Jan 1;2016(MAY).
Ludmir, E. B., et al. “Skeletal muscle metastasis from signet ring cell esophageal adenocarcinoma.” Translational Gastroenterology and Hepatology, vol. 2016, no. MAY, Jan. 2016. Scopus, doi:10.21037/tgh.2016.04.05.
Ludmir EB, Robey B, Shelby E, Patel-Nguyen SV, Rittershaus A, Contarino MR. Skeletal muscle metastasis from signet ring cell esophageal adenocarcinoma. Translational Gastroenterology and Hepatology. 2016 Jan 1;2016(MAY).

Published In

Translational Gastroenterology and Hepatology

DOI

EISSN

2224-4778

ISSN

2224-476X

Publication Date

January 1, 2016

Volume

2016

Issue

MAY

Related Subject Headings

  • 3202 Clinical sciences