NKG2D-mediated activation of cytotoxic lymphocytes: unique signaling pathways and distinct functional outcomes.
Publication
, Journal Article
Upshaw, JL; Leibson, PJ
Published in: Semin Immunol
June 2006
NKG2D is an important immunosurveillance receptor that triggers a unique signal transduction pathway resulting in a variety of functional outcomes. NKG2D couples to the non-ITAM-containing DAP10 and initiates at least two signaling branches that are both required for cytotoxicity. Transformed, infected, or healthy cells can express NKG2D ligands, and NKG2D(+) lymphocytes can be unaffected, costimulated, or fully activated by the NKG2D-ligand interaction. The NKG2D-mediated response can be modulated by factors such as cytokine milieu and possibly the particular ligand expressed. Thus, this nontraditional NKG2D-DAP10 initiated signal pathway enables lymphocytes to differentially respond to ligands based on the cellular environment.
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Published In
Semin Immunol
DOI
ISSN
1044-5323
Publication Date
June 2006
Volume
18
Issue
3
Start / End Page
167 / 175
Location
England
Related Subject Headings
- T-Lymphocytes, Cytotoxic
- Signal Transduction
- Receptors, Natural Killer Cell
- Receptors, Immunologic
- NK Cell Lectin-Like Receptor Subfamily K
- Lymphocyte Activation
- Immunology
- Humans
- Animals
- 3204 Immunology
Citation
APA
Chicago
ICMJE
MLA
NLM
Upshaw, J. L., & Leibson, P. J. (2006). NKG2D-mediated activation of cytotoxic lymphocytes: unique signaling pathways and distinct functional outcomes. Semin Immunol, 18(3), 167–175. https://doi.org/10.1016/j.smim.2006.03.001
Upshaw, Jadee L., and Paul J. Leibson. “NKG2D-mediated activation of cytotoxic lymphocytes: unique signaling pathways and distinct functional outcomes.” Semin Immunol 18, no. 3 (June 2006): 167–75. https://doi.org/10.1016/j.smim.2006.03.001.
Upshaw JL, Leibson PJ. NKG2D-mediated activation of cytotoxic lymphocytes: unique signaling pathways and distinct functional outcomes. Semin Immunol. 2006 Jun;18(3):167–75.
Upshaw, Jadee L., and Paul J. Leibson. “NKG2D-mediated activation of cytotoxic lymphocytes: unique signaling pathways and distinct functional outcomes.” Semin Immunol, vol. 18, no. 3, June 2006, pp. 167–75. Pubmed, doi:10.1016/j.smim.2006.03.001.
Upshaw JL, Leibson PJ. NKG2D-mediated activation of cytotoxic lymphocytes: unique signaling pathways and distinct functional outcomes. Semin Immunol. 2006 Jun;18(3):167–175.
Published In
Semin Immunol
DOI
ISSN
1044-5323
Publication Date
June 2006
Volume
18
Issue
3
Start / End Page
167 / 175
Location
England
Related Subject Headings
- T-Lymphocytes, Cytotoxic
- Signal Transduction
- Receptors, Natural Killer Cell
- Receptors, Immunologic
- NK Cell Lectin-Like Receptor Subfamily K
- Lymphocyte Activation
- Immunology
- Humans
- Animals
- 3204 Immunology