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NLRC3 negatively regulates CD4+ T cells and impacts protective immunity during Mycobacterium tuberculosis infection.

Publication ,  Journal Article
Hu, S; Du, X; Huang, Y; Fu, Y; Yang, Y; Zhan, X; He, W; Wen, Q; Zhou, X; Zhou, C; Zhong, X-P; Yang, J; Xiong, W; Wang, R; Gao, Y; Ma, L
Published in: PLoS Pathog
August 2018

NLRC3, a member of the NLR family, has been reported as a negative regulator of inflammatory signaling pathways in innate immune cells. However, the direct role of NLRC3 in modulation of CD4+ T-cell responses in infectious diseases has not been studied. In the present study, we showed that NLRC3 plays an intrinsic role by suppressing the CD4+ T cell phenotype in lung and spleen, including differentiation, activation, and proliferation. NLRC3 deficiency in CD4+ T cells enhanced the protective immune response against Mycobacterium tuberculosis infection. Finally, we demonstrated that NLRC3 deficiency promoted the activation, proliferation, and cytokine production of CD4+ T cells via negatively regulating the NF-κB and MEK-ERK signaling pathways. This study reveals a critical role of NLRC3 as a direct regulator of the adaptive immune response and its protective effects on immunity during M. tuberculosis infection. Our findings also suggested that NLRC3 serves as a potential target for therapeutic intervention against tuberculosis.

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Published In

PLoS Pathog

DOI

EISSN

1553-7374

Publication Date

August 2018

Volume

14

Issue

8

Start / End Page

e1007266

Location

United States

Related Subject Headings

  • Virology
  • Tuberculosis
  • Mycobacterium tuberculosis
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Intercellular Signaling Peptides and Proteins
  • Immunity
  • Female
 

Citation

APA
Chicago
ICMJE
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Hu, S., Du, X., Huang, Y., Fu, Y., Yang, Y., Zhan, X., … Ma, L. (2018). NLRC3 negatively regulates CD4+ T cells and impacts protective immunity during Mycobacterium tuberculosis infection. PLoS Pathog, 14(8), e1007266. https://doi.org/10.1371/journal.ppat.1007266
Hu, Shengfeng, Xialin Du, Yulan Huang, Yuling Fu, Yalong Yang, Xiaoxia Zhan, Wenting He, et al. “NLRC3 negatively regulates CD4+ T cells and impacts protective immunity during Mycobacterium tuberculosis infection.PLoS Pathog 14, no. 8 (August 2018): e1007266. https://doi.org/10.1371/journal.ppat.1007266.
Hu S, Du X, Huang Y, Fu Y, Yang Y, Zhan X, et al. NLRC3 negatively regulates CD4+ T cells and impacts protective immunity during Mycobacterium tuberculosis infection. PLoS Pathog. 2018 Aug;14(8):e1007266.
Hu, Shengfeng, et al. “NLRC3 negatively regulates CD4+ T cells and impacts protective immunity during Mycobacterium tuberculosis infection.PLoS Pathog, vol. 14, no. 8, Aug. 2018, p. e1007266. Pubmed, doi:10.1371/journal.ppat.1007266.
Hu S, Du X, Huang Y, Fu Y, Yang Y, Zhan X, He W, Wen Q, Zhou X, Zhou C, Zhong X-P, Yang J, Xiong W, Wang R, Gao Y, Ma L. NLRC3 negatively regulates CD4+ T cells and impacts protective immunity during Mycobacterium tuberculosis infection. PLoS Pathog. 2018 Aug;14(8):e1007266.

Published In

PLoS Pathog

DOI

EISSN

1553-7374

Publication Date

August 2018

Volume

14

Issue

8

Start / End Page

e1007266

Location

United States

Related Subject Headings

  • Virology
  • Tuberculosis
  • Mycobacterium tuberculosis
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Intercellular Signaling Peptides and Proteins
  • Immunity
  • Female