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Moving from the Trial to the Real World: Improving Medication Adherence Using Insights of Implementation Science.

Publication ,  Journal Article
Zullig, LL; Deschodt, M; Liska, J; Bosworth, HB; De Geest, S
Published in: Annu Rev Pharmacol Toxicol
January 6, 2019

Medication nonadherence is a serious public health concern. Although there are promising interventions that improve medication adherence, most interventions are developed and tested in tightly controlled research environments that are dissimilar from the real-world settings where the majority of patients receive health care. Implementation science methods have the potential to facilitate and accelerate the translation shift from the trial world to the real world. We demonstrate their potential by reviewing published, high-quality medication adherence studies that could potentially be translated into clinical practice yet lack essential implementation science building blocks. We further illustrate this point by describing an adherence study that demonstrates how implementation science creates a junction between research and real-world settings. This article is a call to action for researchers, clinicians, policy makers, pharmaceutical companies, and others involved in the delivery of care to adopt the implementation science paradigm in the scale-up of adherence (research) programs.

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Published In

Annu Rev Pharmacol Toxicol

DOI

EISSN

1545-4304

Publication Date

January 6, 2019

Volume

59

Start / End Page

423 / 445

Location

United States

Related Subject Headings

  • Pharmacology & Pharmacy
  • Medication Adherence
  • Implementation Science
  • Humans
  • Drug Industry
  • Delivery of Health Care
  • 3214 Pharmacology and pharmaceutical sciences
  • 11 Medical and Health Sciences
  • 06 Biological Sciences
 

Citation

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MLA
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Zullig, L. L., Deschodt, M., Liska, J., Bosworth, H. B., & De Geest, S. (2019). Moving from the Trial to the Real World: Improving Medication Adherence Using Insights of Implementation Science. Annu Rev Pharmacol Toxicol, 59, 423–445. https://doi.org/10.1146/annurev-pharmtox-010818-021348
Zullig, Leah L., Mieke Deschodt, Jan Liska, Hayden B. Bosworth, and Sabina De Geest. “Moving from the Trial to the Real World: Improving Medication Adherence Using Insights of Implementation Science.Annu Rev Pharmacol Toxicol 59 (January 6, 2019): 423–45. https://doi.org/10.1146/annurev-pharmtox-010818-021348.
Zullig LL, Deschodt M, Liska J, Bosworth HB, De Geest S. Moving from the Trial to the Real World: Improving Medication Adherence Using Insights of Implementation Science. Annu Rev Pharmacol Toxicol. 2019 Jan 6;59:423–45.
Zullig, Leah L., et al. “Moving from the Trial to the Real World: Improving Medication Adherence Using Insights of Implementation Science.Annu Rev Pharmacol Toxicol, vol. 59, Jan. 2019, pp. 423–45. Pubmed, doi:10.1146/annurev-pharmtox-010818-021348.
Zullig LL, Deschodt M, Liska J, Bosworth HB, De Geest S. Moving from the Trial to the Real World: Improving Medication Adherence Using Insights of Implementation Science. Annu Rev Pharmacol Toxicol. 2019 Jan 6;59:423–445.

Published In

Annu Rev Pharmacol Toxicol

DOI

EISSN

1545-4304

Publication Date

January 6, 2019

Volume

59

Start / End Page

423 / 445

Location

United States

Related Subject Headings

  • Pharmacology & Pharmacy
  • Medication Adherence
  • Implementation Science
  • Humans
  • Drug Industry
  • Delivery of Health Care
  • 3214 Pharmacology and pharmaceutical sciences
  • 11 Medical and Health Sciences
  • 06 Biological Sciences