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Combinations of DIPs and Dprs control organization of olfactory receptor neuron terminals in Drosophila.

Publication ,  Journal Article
Barish, S; Nuss, S; Strunilin, I; Bao, S; Mukherjee, S; Jones, CD; Volkan, PC
Published in: PLoS genetics
August 2018

In Drosophila, 50 classes of olfactory receptor neurons (ORNs) connect to 50 class-specific and uniquely positioned glomeruli in the antennal lobe. Despite the identification of cell surface receptors regulating axon guidance, how ORN axons sort to form 50 stereotypical glomeruli remains unclear. Here we show that the heterophilic cell adhesion proteins, DIPs and Dprs, are expressed in ORNs during glomerular formation. Many ORN classes express a unique combination of DIPs/dprs, with neurons of the same class expressing interacting partners, suggesting a role in class-specific self-adhesion between ORN axons. Analysis of DIP/Dpr expression revealed that ORNs that target neighboring glomeruli have different combinations, and ORNs with very similar DIP/Dpr combinations can project to distant glomeruli in the antennal lobe. DIP/Dpr profiles are dynamic during development and correlate with sensilla type lineage for some ORN classes. Perturbations of DIP/dpr gene function result in local projection defects of ORN axons and glomerular positioning, without altering correct matching of ORNs with their target neurons. Our results suggest that context-dependent differential adhesion through DIP/Dpr combinations regulate self-adhesion and sort ORN axons into uniquely positioned glomeruli.

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Published In

PLoS genetics

DOI

EISSN

1553-7404

ISSN

1553-7390

Publication Date

August 2018

Volume

14

Issue

8

Start / End Page

e1007560

Related Subject Headings

  • Sequence Analysis, RNA
  • Olfactory Receptor Neurons
  • Olfactory Pathways
  • Models, Theoretical
  • Genotyping Techniques
  • Gene Expression Regulation
  • Drosophila Proteins
  • Drosophila
  • Developmental Biology
  • Cell Adhesion
 

Citation

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Barish, S., Nuss, S., Strunilin, I., Bao, S., Mukherjee, S., Jones, C. D., & Volkan, P. C. (2018). Combinations of DIPs and Dprs control organization of olfactory receptor neuron terminals in Drosophila. PLoS Genetics, 14(8), e1007560. https://doi.org/10.1371/journal.pgen.1007560
Barish, Scott, Sarah Nuss, Ilya Strunilin, Suyang Bao, Sayan Mukherjee, Corbin D. Jones, and Pelin C. Volkan. “Combinations of DIPs and Dprs control organization of olfactory receptor neuron terminals in Drosophila.PLoS Genetics 14, no. 8 (August 2018): e1007560. https://doi.org/10.1371/journal.pgen.1007560.
Barish S, Nuss S, Strunilin I, Bao S, Mukherjee S, Jones CD, et al. Combinations of DIPs and Dprs control organization of olfactory receptor neuron terminals in Drosophila. PLoS genetics. 2018 Aug;14(8):e1007560.
Barish, Scott, et al. “Combinations of DIPs and Dprs control organization of olfactory receptor neuron terminals in Drosophila.PLoS Genetics, vol. 14, no. 8, Aug. 2018, p. e1007560. Epmc, doi:10.1371/journal.pgen.1007560.
Barish S, Nuss S, Strunilin I, Bao S, Mukherjee S, Jones CD, Volkan PC. Combinations of DIPs and Dprs control organization of olfactory receptor neuron terminals in Drosophila. PLoS genetics. 2018 Aug;14(8):e1007560.

Published In

PLoS genetics

DOI

EISSN

1553-7404

ISSN

1553-7390

Publication Date

August 2018

Volume

14

Issue

8

Start / End Page

e1007560

Related Subject Headings

  • Sequence Analysis, RNA
  • Olfactory Receptor Neurons
  • Olfactory Pathways
  • Models, Theoretical
  • Genotyping Techniques
  • Gene Expression Regulation
  • Drosophila Proteins
  • Drosophila
  • Developmental Biology
  • Cell Adhesion