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Postoperative oxycodone toxicity in a patient with chronic pain and end-stage renal disease.

Publication ,  Journal Article
Tran, BW; Kohan, LR; Vorenkamp, KE
Published in: A A Case Rep
February 15, 2015

We present this case to review the metabolism of oxycodone and the effects of end-stage renal disease on the elimination of oxycodone and its metabolites. A 42-year-old female with end-stage renal disease who was dependent on hemodialysis presented for left hamstring posterior capsule release. She had been receiving methadone for 2 years for chronic leg pain. On postoperative day 1, the patient's medication was changed from IV hydromorphone to oral oxycodone to treat breakthrough pain. By the next day, the patient was unarousable with notable respiratory depression. She did not fully recover after urgent hemodialysis but did have full recovery after receiving an IV naloxone infusion for 22 hours. Further study of the safety of oxycodone in hemodialysis patients is warranted.

Duke Scholars

Published In

A A Case Rep

DOI

EISSN

2325-7237

Publication Date

February 15, 2015

Volume

4

Issue

4

Start / End Page

44 / 46

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Respiratory Insufficiency
  • Renal Dialysis
  • Pain, Postoperative
  • Oxycodone
  • Narcotic Antagonists
  • Naloxone
  • Leg
  • Kidney Failure, Chronic
  • Joint Capsule Release
 

Citation

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Tran, B. W., Kohan, L. R., & Vorenkamp, K. E. (2015). Postoperative oxycodone toxicity in a patient with chronic pain and end-stage renal disease. A A Case Rep, 4(4), 44–46. https://doi.org/10.1213/XAA.0000000000000115
Tran, Bryant W., Lynn R. Kohan, and Kevin E. Vorenkamp. “Postoperative oxycodone toxicity in a patient with chronic pain and end-stage renal disease.A A Case Rep 4, no. 4 (February 15, 2015): 44–46. https://doi.org/10.1213/XAA.0000000000000115.
Tran BW, Kohan LR, Vorenkamp KE. Postoperative oxycodone toxicity in a patient with chronic pain and end-stage renal disease. A A Case Rep. 2015 Feb 15;4(4):44–6.
Tran, Bryant W., et al. “Postoperative oxycodone toxicity in a patient with chronic pain and end-stage renal disease.A A Case Rep, vol. 4, no. 4, Feb. 2015, pp. 44–46. Pubmed, doi:10.1213/XAA.0000000000000115.
Tran BW, Kohan LR, Vorenkamp KE. Postoperative oxycodone toxicity in a patient with chronic pain and end-stage renal disease. A A Case Rep. 2015 Feb 15;4(4):44–46.

Published In

A A Case Rep

DOI

EISSN

2325-7237

Publication Date

February 15, 2015

Volume

4

Issue

4

Start / End Page

44 / 46

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Respiratory Insufficiency
  • Renal Dialysis
  • Pain, Postoperative
  • Oxycodone
  • Narcotic Antagonists
  • Naloxone
  • Leg
  • Kidney Failure, Chronic
  • Joint Capsule Release