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Analysis of Successful Versus Failed Radiographic Outcomes After Cervical Deformity Surgery.

Publication ,  Journal Article
Protopsaltis, TS; Ramchandran, S; Hamilton, DK; Sciubba, D; Passias, PG; Lafage, V; Lafage, R; Smith, JS; Hart, RA; Gupta, M; Burton, D ...
Published in: Spine (Phila Pa 1976)
July 1, 2018

STUDY DESIGN: Prospective multicenter cohort study with consecutive enrollment. OBJECTIVE: To evaluate preoperative alignment and surgical factors associated with suboptimal early postoperative radiographic outcomes after surgery for cervical deformity. SUMMARY OF BACKGROUND DATA: Recent studies have demonstrated correlation between cervical sagittal alignment and patient-reported outcomes. Few studies have explored cervical deformity correction prospectively, and the factors that result in successful versus failed cervical alignment corrections remain unclear. METHODS: Patients with adult cervical deformity (ACD) included with either cervical kyphosis more than 10°, C2-C7 sagittal vertical axis (cSVA) of more than 4 cm, or chin-brow vertical angle of more than 25°. Patients were categorized into failed outcomes group if cSVA of more than 4 cm or T1 slope and cervical lordosis (TS-CL) of more than 20° at 6 months postoperatively. RESULTS: A total of 71 patients with ACD (mean age 62 yr, 56% women, 41% revisions) were included. Fourty-five had primary cervical deformities and 26 at the cervico-thoracic junction. Thirty-three (46.4%) had failed radiographic outcomes by cSVA and 46 (64.7%) by TS-CL. Failure to restore cSVA was associated with worse preoperative C2 pelvic tilt angle (CPT: 64.4° vs. 47.8°, P = 0.01), worse postoperative C2 slope (35.0° vs. 23.8°, P = 0.004), TS-CL (35.2° vs. 24.9°, P = 0.01), CPT (47.9° vs. 28.2°, P < 0.001), "+" Schwab modifiers (P = 0.007), revision surgery (P = 0.05), and failure to address the secondary, thoracolumbar driver of the deformity (P = 0.02). Failure to correct TS-CL was associated with worse preoperative cervical kyphosis (10.4° vs. -2.1°, P = 0.03), CPT (52.6° vs. 39.1°, P = 0.04), worse postoperative C2 slope (30.2° vs. 13.3°, P < 0.001), cervical lordosis (-3.6° vs. -15.1°, P = 0.01), and CPT (37.7° vs. 24.0°, P < 0.001). Multivariate analysis revealed postoperative distal junctional kyphosis associated with suboptimal outcomes by cSVA (odds ratio 0.06, confidence interval 0.01-0.4, P = 0.004) and TS-CL (odds ratio 0.15, confidence interval 0.02-0.97, P = 0.05). CONCLUSION: Factors associated with failure to correct the cSVA included revision surgery, worse preoperative CPT, and concurrent thoracolumbar deformity. Failure to correct the TS-CL mismatch was associated with worse preoperative cervical kyphosis and CPT. Occurrence of early postoperative distal junctional kyphosis significantly affects postoperative radiographic outcomes. LEVEL OF EVIDENCE: 3.

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Published In

Spine (Phila Pa 1976)

DOI

EISSN

1528-1159

Publication Date

July 1, 2018

Volume

43

Issue

13

Start / End Page

E773 / E781

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Treatment Failure
  • Prospective Studies
  • Orthopedics
  • Middle Aged
  • Male
  • Kyphosis
  • Humans
  • Follow-Up Studies
  • Female
 

Citation

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Protopsaltis, T. S., Ramchandran, S., Hamilton, D. K., Sciubba, D., Passias, P. G., Lafage, V., … International Spine Study Group (ISSG), . (2018). Analysis of Successful Versus Failed Radiographic Outcomes After Cervical Deformity Surgery. Spine (Phila Pa 1976), 43(13), E773–E781. https://doi.org/10.1097/BRS.0000000000002524
Protopsaltis, Themistocles S., Subaraman Ramchandran, D Kojo Hamilton, Daniel Sciubba, Peter G. Passias, Virginie Lafage, Renaud Lafage, et al. “Analysis of Successful Versus Failed Radiographic Outcomes After Cervical Deformity Surgery.Spine (Phila Pa 1976) 43, no. 13 (July 1, 2018): E773–81. https://doi.org/10.1097/BRS.0000000000002524.
Protopsaltis TS, Ramchandran S, Hamilton DK, Sciubba D, Passias PG, Lafage V, et al. Analysis of Successful Versus Failed Radiographic Outcomes After Cervical Deformity Surgery. Spine (Phila Pa 1976). 2018 Jul 1;43(13):E773–81.
Protopsaltis, Themistocles S., et al. “Analysis of Successful Versus Failed Radiographic Outcomes After Cervical Deformity Surgery.Spine (Phila Pa 1976), vol. 43, no. 13, July 2018, pp. E773–81. Pubmed, doi:10.1097/BRS.0000000000002524.
Protopsaltis TS, Ramchandran S, Hamilton DK, Sciubba D, Passias PG, Lafage V, Lafage R, Smith JS, Hart RA, Gupta M, Burton D, Bess S, Shaffrey C, Ames CP, International Spine Study Group (ISSG). Analysis of Successful Versus Failed Radiographic Outcomes After Cervical Deformity Surgery. Spine (Phila Pa 1976). 2018 Jul 1;43(13):E773–E781.

Published In

Spine (Phila Pa 1976)

DOI

EISSN

1528-1159

Publication Date

July 1, 2018

Volume

43

Issue

13

Start / End Page

E773 / E781

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Treatment Failure
  • Prospective Studies
  • Orthopedics
  • Middle Aged
  • Male
  • Kyphosis
  • Humans
  • Follow-Up Studies
  • Female