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Prevalence and type of cervical deformities among adults with Parkinson's disease: a cross-sectional study.

Publication ,  Journal Article
Moon, BJ; Smith, JS; Ames, CP; Shaffrey, CI; Lafage, V; Schwab, F; Matsumoto, M; Baik, JS; Ha, Y
Published in: J Neurosurg Spine
April 2016

OBJECT: To identify the characteristics of cervical deformities in Parkinson's disease (PD) and the role of severity of PD in the development of cervical spine deformities, the authors investigated the prevalence of the cervical deformities, cervical kyphosis (CK), and cervical positive sagittal malalignment (CPSM) in patients with PD. They also analyzed the association of severity of cervical deformities with the stage of PD in the context of global sagittal spinopelvic alignment. METHODS: This study was a prospective assessment of consecutively treated patients (n = 89) with PD. A control group of the age- and sex-matched patients was selected from patients with degenerative cervical spine disease but without PD. Clinical and demographic parameters including age, sex, duration of PD, and Hoehn and Yahr (H&Y) stage were collected. Full-length standing radiographs were used to assess spinopelvic parameters. CK was defined as a C2-7 Cobb angle < 0°. CPSM was defined as C2-7 sagittal vertical axis (SVA) > 4 cm. RESULTS: A significantly higher prevalence of CPSM (28% vs. 1.1%, p < 0.001), but not CK (12% vs. 10.1%, p = 0.635), was found in PD patients compared with control patients. Among patients with PD, those with CK were younger (62.1 vs. 69.0 years, p = 0.013) and had longer duration of PD (56.4 vs. 36.2 months, p = 0.034), but the severity of PD was not significantly different. Logistic regression analysis revealed that the presence of CK was associated with younger age, higher mismatch between pelvic incidence and lumbar lordosis, and lower C7-S1 SVA. The patients with CPSM had significantly greater thoracic kyphosis (TK) (p < 0.001) and a trend toward more advanced H&Y stage (p = 0.05). Logistic regression analysis revealed that CPSM was associated with male sex, greater TK, and more advanced H&Y stage. CONCLUSIONS: Patients with PD have a significantly higher prevalence of CPSM compared with age- and sex-matched control patients with cervical degenerative disease but without PD. Among patients with PD, CK is not associated with the severity of PD but is associated with overall global sagittal malalignment. In contrast, the presence of CPSM is associated more with the severity of PD than it is with the presence of global sagittal malalignment. Collectively, these data suggest that the neuromuscular pathogenesis of PD may affect the development of CPSM more than of CK.

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Published In

J Neurosurg Spine

DOI

EISSN

1547-5646

Publication Date

April 2016

Volume

24

Issue

4

Start / End Page

527 / 534

Location

United States

Related Subject Headings

  • Young Adult
  • Thoracic Vertebrae
  • Scoliosis
  • Prevalence
  • Posture
  • Parkinson Disease
  • Orthopedics
  • Neck
  • Middle Aged
  • Male
 

Citation

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Moon, B. J., Smith, J. S., Ames, C. P., Shaffrey, C. I., Lafage, V., Schwab, F., … Ha, Y. (2016). Prevalence and type of cervical deformities among adults with Parkinson's disease: a cross-sectional study. J Neurosurg Spine, 24(4), 527–534. https://doi.org/10.3171/2015.6.SPINE141197
Moon, Bong Ju, Justin S. Smith, Christopher P. Ames, Christopher I. Shaffrey, Virginie Lafage, Frank Schwab, Morio Matsumoto, Jong Sam Baik, and Yoon Ha. “Prevalence and type of cervical deformities among adults with Parkinson's disease: a cross-sectional study.J Neurosurg Spine 24, no. 4 (April 2016): 527–34. https://doi.org/10.3171/2015.6.SPINE141197.
Moon BJ, Smith JS, Ames CP, Shaffrey CI, Lafage V, Schwab F, et al. Prevalence and type of cervical deformities among adults with Parkinson's disease: a cross-sectional study. J Neurosurg Spine. 2016 Apr;24(4):527–34.
Moon, Bong Ju, et al. “Prevalence and type of cervical deformities among adults with Parkinson's disease: a cross-sectional study.J Neurosurg Spine, vol. 24, no. 4, Apr. 2016, pp. 527–34. Pubmed, doi:10.3171/2015.6.SPINE141197.
Moon BJ, Smith JS, Ames CP, Shaffrey CI, Lafage V, Schwab F, Matsumoto M, Baik JS, Ha Y. Prevalence and type of cervical deformities among adults with Parkinson's disease: a cross-sectional study. J Neurosurg Spine. 2016 Apr;24(4):527–534.

Published In

J Neurosurg Spine

DOI

EISSN

1547-5646

Publication Date

April 2016

Volume

24

Issue

4

Start / End Page

527 / 534

Location

United States

Related Subject Headings

  • Young Adult
  • Thoracic Vertebrae
  • Scoliosis
  • Prevalence
  • Posture
  • Parkinson Disease
  • Orthopedics
  • Neck
  • Middle Aged
  • Male