Skip to main content

Donor-reactive T-cell stimulation history and precursor frequency: barriers to tolerance induction.

Publication ,  Journal Article
Ford, ML; Kirk, AD; Larsen, CP
Published in: Transplantation
May 15, 2009

Blockade of T-cell costimulatory pathways represents a potent and specific method of preventing naïve antidonor T-cell responses after transplantation in mouse, monkey, and man. However, numerous studies have shown that the presence of donor-reactive memory T cells in the recipient poses a sometimes insurmountable barrier to long-term graft survival and tolerance induction. Here, we discuss the ways in which donor-reactive memory T cells may arise from environmental exposure to pathogens. Pathogen-specific memory T cells, by virtue of the inherent degeneracy of T-cell receptor recognition of peptide:major histocompatibility complex ligands, may exhibit cross reactivity with allogeneic peptide:major histocompatibility complexes and thereby mediate graft rejection. From the recent explosion in knowledge of the heterogeneity of memory T-cell resulting from variations in frequency and duration of antigen exposure, cytokine milieu, site of priming, and a host of other factors, it is becoming increasingly well appreciated that different memory T-cell populations may exhibit differential susceptibilities to tolerance induction. Thus, the immune history of a transplant recipient and frequencies of donor-cross-reactive memory T cells within the various compartments may dictate the likelihood of success or failure of tolerance induction.

Duke Scholars

Published In

Transplantation

DOI

EISSN

1534-6080

Publication Date

May 15, 2009

Volume

87

Issue

9 Suppl

Start / End Page

S69 / S74

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Transplantation Tolerance
  • T-Lymphocytes
  • Surgery
  • Lymphocyte Activation
  • Kidney Transplantation
  • Immunologic Memory
  • Immune Tolerance
  • Humans
  • Graft Survival
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ford, M. L., Kirk, A. D., & Larsen, C. P. (2009). Donor-reactive T-cell stimulation history and precursor frequency: barriers to tolerance induction. Transplantation, 87(9 Suppl), S69–S74. https://doi.org/10.1097/TP.0b013e3181a2a701
Ford, Mandy L., Allan D. Kirk, and Christian P. Larsen. “Donor-reactive T-cell stimulation history and precursor frequency: barriers to tolerance induction.Transplantation 87, no. 9 Suppl (May 15, 2009): S69–74. https://doi.org/10.1097/TP.0b013e3181a2a701.
Ford ML, Kirk AD, Larsen CP. Donor-reactive T-cell stimulation history and precursor frequency: barriers to tolerance induction. Transplantation. 2009 May 15;87(9 Suppl):S69–74.
Ford, Mandy L., et al. “Donor-reactive T-cell stimulation history and precursor frequency: barriers to tolerance induction.Transplantation, vol. 87, no. 9 Suppl, May 2009, pp. S69–74. Pubmed, doi:10.1097/TP.0b013e3181a2a701.
Ford ML, Kirk AD, Larsen CP. Donor-reactive T-cell stimulation history and precursor frequency: barriers to tolerance induction. Transplantation. 2009 May 15;87(9 Suppl):S69–S74.

Published In

Transplantation

DOI

EISSN

1534-6080

Publication Date

May 15, 2009

Volume

87

Issue

9 Suppl

Start / End Page

S69 / S74

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Transplantation Tolerance
  • T-Lymphocytes
  • Surgery
  • Lymphocyte Activation
  • Kidney Transplantation
  • Immunologic Memory
  • Immune Tolerance
  • Humans
  • Graft Survival