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Simvastatin suppresses cyclophosphamide-induced changes in urodynamics and bladder inflammation.

Publication ,  Journal Article
Hughes, FM; McKeithan, P; Ellett, J; Armeson, KE; Purves, JT
Published in: Urology
January 2013

OBJECTIVE: To assess the ability of daily oral simvastatin administration to reduce the negative urodynamic changes associated with cyclophosphamide (CP)-induced cystitis and to prevent bladder inflammation. Patients undergoing CP chemotherapy frequently develop cystitis, leading to urinary dysfunction and hemorrhage. Recent studies have suggested statins possess anti-inflammatory properties and might be uroprotective. MATERIALS AND METHODS: Urodynamic properties were analyzed in 4 groups of female Sprague-Dawley rats: group 1, vehicle (300 μL, 0.5% methylcellulose, orally for 7 days); group 2, simvastatin (1 mg/rat/d); group 3, vehicle plus CP (intraperitoneally 80 mg/kg, 24 h before cystometry); and group 4, simvastatin plus CP. The inflammation in the groups was assessed using Evans blue extravasation. RESULTS: CP stimulated significant increases in the number of nonvoiding contractions (0.83±0.26 vs 4.97±1.90; P=.03) and decreases in the peak voiding pressure (53.46±5.08 vs 33.34±4.37 cm H2O; P=.01). Simvastatin returned these parameters to the control levels of 1.62±0.73 (P=.70) and 45.98±7.78 cm H2O (P=.38). CP at this level caused a slight, but significant, increase in the voided volume (0.82±0.13 vs 1.16±0.14 mL; P=.04), which returned to control levels (0.74±0.12 mL; P=.65) with simvastatin. Other urodynamic parameters, such as the threshold pressure, were not affected by simvastatin or CP, or the combination of the 2. CP-induced inflammation in the bladder (Evans blue extravasation) was suppressed by simvastatin. CONCLUSION: Simvastatin was effective at ameliorating the negative urodynamic changes and inflammation in the bladder after CP administration and is a potential therapy for preventing side effects in patients undergoing this chemotherapy.

Duke Scholars

Published In

Urology

DOI

EISSN

1527-9995

Publication Date

January 2013

Volume

81

Issue

1

Start / End Page

209.e9 / 209.14

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Urodynamics
  • Urine
  • Urination
  • Urinary Bladder
  • Simvastatin
  • Rats, Sprague-Dawley
  • Rats
  • Pressure
  • Muscle Contraction
 

Citation

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ICMJE
MLA
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Hughes, F. M., McKeithan, P., Ellett, J., Armeson, K. E., & Purves, J. T. (2013). Simvastatin suppresses cyclophosphamide-induced changes in urodynamics and bladder inflammation. Urology, 81(1), 209.e9-209.14. https://doi.org/10.1016/j.urology.2012.08.041
Hughes, Francis M., Paige McKeithan, Justin Ellett, Kent E. Armeson, and J Todd Purves. “Simvastatin suppresses cyclophosphamide-induced changes in urodynamics and bladder inflammation.Urology 81, no. 1 (January 2013): 209.e9-209.14. https://doi.org/10.1016/j.urology.2012.08.041.
Hughes FM, McKeithan P, Ellett J, Armeson KE, Purves JT. Simvastatin suppresses cyclophosphamide-induced changes in urodynamics and bladder inflammation. Urology. 2013 Jan;81(1):209.e9-209.14.
Hughes, Francis M., et al. “Simvastatin suppresses cyclophosphamide-induced changes in urodynamics and bladder inflammation.Urology, vol. 81, no. 1, Jan. 2013, pp. 209.e9-209.14. Pubmed, doi:10.1016/j.urology.2012.08.041.
Hughes FM, McKeithan P, Ellett J, Armeson KE, Purves JT. Simvastatin suppresses cyclophosphamide-induced changes in urodynamics and bladder inflammation. Urology. 2013 Jan;81(1):209.e9-209.14.
Journal cover image

Published In

Urology

DOI

EISSN

1527-9995

Publication Date

January 2013

Volume

81

Issue

1

Start / End Page

209.e9 / 209.14

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Urodynamics
  • Urine
  • Urination
  • Urinary Bladder
  • Simvastatin
  • Rats, Sprague-Dawley
  • Rats
  • Pressure
  • Muscle Contraction