Synthesis and biological characterization of sqbazide, a novel biotinylated photoaffinity probe for the study of the human platelet thromboxane A2 receptor.
Publication
, Journal Article
Halmos, T; Turek, JW; Le Breton, GC; Antonakis, K
Published in: Bioorg Med Chem Lett
October 18, 1999
SQBAzide, a biotinylated, azido derivative of the TXA2 receptor antagonist, SQ31,491, was synthesized and characterized. The compound specifically inhibited human platelet aggregation mediated by TXA2 receptor activation and irreversibly labeled platelet TXA2 receptors upon exposure to ultraviolet light. This probe should prove to be of significant value for the study of the receptor-ligand binding domain.
Duke Scholars
Published In
Bioorg Med Chem Lett
DOI
ISSN
0960-894X
Publication Date
October 18, 1999
Volume
9
Issue
20
Start / End Page
2963 / 2968
Location
England
Related Subject Headings
- Receptors, Thromboxane
- Platelet Aggregation Inhibitors
- Photoaffinity Labels
- Medicinal & Biomolecular Chemistry
- Humans
- Blood Platelets
- Biotin
- Azides
- 3405 Organic chemistry
- 3404 Medicinal and biomolecular chemistry
Citation
APA
Chicago
ICMJE
MLA
NLM
Halmos, T., Turek, J. W., Le Breton, G. C., & Antonakis, K. (1999). Synthesis and biological characterization of sqbazide, a novel biotinylated photoaffinity probe for the study of the human platelet thromboxane A2 receptor. Bioorg Med Chem Lett, 9(20), 2963–2968. https://doi.org/10.1016/s0960-894x(99)00511-9
Halmos, T., J. W. Turek, G. C. Le Breton, and K. Antonakis. “Synthesis and biological characterization of sqbazide, a novel biotinylated photoaffinity probe for the study of the human platelet thromboxane A2 receptor.” Bioorg Med Chem Lett 9, no. 20 (October 18, 1999): 2963–68. https://doi.org/10.1016/s0960-894x(99)00511-9.
Halmos T, Turek JW, Le Breton GC, Antonakis K. Synthesis and biological characterization of sqbazide, a novel biotinylated photoaffinity probe for the study of the human platelet thromboxane A2 receptor. Bioorg Med Chem Lett. 1999 Oct 18;9(20):2963–8.
Halmos, T., et al. “Synthesis and biological characterization of sqbazide, a novel biotinylated photoaffinity probe for the study of the human platelet thromboxane A2 receptor.” Bioorg Med Chem Lett, vol. 9, no. 20, Oct. 1999, pp. 2963–68. Pubmed, doi:10.1016/s0960-894x(99)00511-9.
Halmos T, Turek JW, Le Breton GC, Antonakis K. Synthesis and biological characterization of sqbazide, a novel biotinylated photoaffinity probe for the study of the human platelet thromboxane A2 receptor. Bioorg Med Chem Lett. 1999 Oct 18;9(20):2963–2968.
Published In
Bioorg Med Chem Lett
DOI
ISSN
0960-894X
Publication Date
October 18, 1999
Volume
9
Issue
20
Start / End Page
2963 / 2968
Location
England
Related Subject Headings
- Receptors, Thromboxane
- Platelet Aggregation Inhibitors
- Photoaffinity Labels
- Medicinal & Biomolecular Chemistry
- Humans
- Blood Platelets
- Biotin
- Azides
- 3405 Organic chemistry
- 3404 Medicinal and biomolecular chemistry