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The Role of Biliary Carcinoembryonic Antigen-Related Cellular Adhesion Molecule 6 (CEACAM6) as a Biomarker in Cholangiocarcinoma.

Publication ,  Journal Article
Rose, JB; Correa-Gallego, C; Li, Y; Nelson, J; Alseidi, A; Helton, WS; Allen, PJ; D'Angelica, MI; DeMatteo, RP; Fong, Y; Kingham, TP ...
Published in: PLoS One
2016

OBJECTIVE: The aim of the present study is to determine if CEACAM6 can be detected in the bile of patients with biliary cancer and can serve as a diagnostic biomarker for cholangiocarcinoma. SUMMARY BACKGROUND DATA: Distinguishing bile duct carcinoma from other diagnoses is often difficult using endoscopic or percutaneous techniques. The cell surface protein CEACAM6 is over-expressed in many gastrointestinal cancers and may be selectively elevated in biliary adenocarcinoma. METHODS: Bile from patients with benign biliary disease and cholangiocarcinoma (hilar, intrahepatic and distal) was collected at the time of index operation. The concentration of CEACAM6 was quantified by sandwich enzyme-linked immunosorbent assay (ELISA) and correlated to pathologic diagnosis. Diagnostic capability of CEACAM6 was evaluated by Wilcoxon rank-sum, linear regression, multiple regression, and receiver operating characteristic (ROC) curve analysis. RESULTS: Bile from 83 patients was analyzed: 42 with benign disease and 41 with cholangiocarcinoma. Patients in the benign cohort were younger, predominantly female, and had lower median biliary CEACAM6 levels than patients in the malignant cohort (7.5 ng/ml vs. 40 ng/ml; p = <.001). ROC curve analysis determined CEACAM6 to be a positive predictor cholangiocarcinoma with a CEACAM6 level >14 ng/ml associated with 87.5% sensitivity, 69.1% specificity, and a likelihood ratio of 2.8 (AUC 0.74). Multiple regression analysis suggested elevated alkaline phosphatase and the presence of biliary endoprostheses may influence CEACAM6 levels. CONCLUSION: Biliary CEACAM6 can identify patients with extrahepatic cholangiocarcinoma with a high degree of sensitivity and should be investigated further as a potential screening tool.

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Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2016

Volume

11

Issue

3

Start / End Page

e0150195

Location

United States

Related Subject Headings

  • Neoplasm Proteins
  • Middle Aged
  • Male
  • Humans
  • General Science & Technology
  • GPI-Linked Proteins
  • Female
  • Cohort Studies
  • Cholangiocarcinoma
  • Cell Adhesion Molecules
 

Citation

APA
Chicago
ICMJE
MLA
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Rose, J. B., Correa-Gallego, C., Li, Y., Nelson, J., Alseidi, A., Helton, W. S., … Rocha, F. G. (2016). The Role of Biliary Carcinoembryonic Antigen-Related Cellular Adhesion Molecule 6 (CEACAM6) as a Biomarker in Cholangiocarcinoma. PLoS One, 11(3), e0150195. https://doi.org/10.1371/journal.pone.0150195
Rose, J Bart, Camilo Correa-Gallego, Yu Li, James Nelson, Adnan Alseidi, W Scott Helton, Peter J. Allen, et al. “The Role of Biliary Carcinoembryonic Antigen-Related Cellular Adhesion Molecule 6 (CEACAM6) as a Biomarker in Cholangiocarcinoma.PLoS One 11, no. 3 (2016): e0150195. https://doi.org/10.1371/journal.pone.0150195.
Rose JB, Correa-Gallego C, Li Y, Nelson J, Alseidi A, Helton WS, et al. The Role of Biliary Carcinoembryonic Antigen-Related Cellular Adhesion Molecule 6 (CEACAM6) as a Biomarker in Cholangiocarcinoma. PLoS One. 2016;11(3):e0150195.
Rose, J. Bart, et al. “The Role of Biliary Carcinoembryonic Antigen-Related Cellular Adhesion Molecule 6 (CEACAM6) as a Biomarker in Cholangiocarcinoma.PLoS One, vol. 11, no. 3, 2016, p. e0150195. Pubmed, doi:10.1371/journal.pone.0150195.
Rose JB, Correa-Gallego C, Li Y, Nelson J, Alseidi A, Helton WS, Allen PJ, D’Angelica MI, DeMatteo RP, Fong Y, Kingham TP, Kowdley KV, Jarnagin WR, Rocha FG. The Role of Biliary Carcinoembryonic Antigen-Related Cellular Adhesion Molecule 6 (CEACAM6) as a Biomarker in Cholangiocarcinoma. PLoS One. 2016;11(3):e0150195.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2016

Volume

11

Issue

3

Start / End Page

e0150195

Location

United States

Related Subject Headings

  • Neoplasm Proteins
  • Middle Aged
  • Male
  • Humans
  • General Science & Technology
  • GPI-Linked Proteins
  • Female
  • Cohort Studies
  • Cholangiocarcinoma
  • Cell Adhesion Molecules