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T cell infiltrate and outcome following resection of intermediate-grade primary neuroendocrine tumours and liver metastases

Publication ,  Journal Article
Katz, SC; Donkor, C; Glasgow, K; Pillarisetty, VG; Gönen, M; Espat, NJ; Klimstra, DS; D'Angelica, MI; Allen, PJ; Jarnagin, W; Dematteo, RP ...
Published in: HPB
January 1, 2010

Background: Tumour-infiltrating lymphocytes (TILs) have been shown to predict survival in numerous malignancies. The importance of TILs in primary pancreatic neuroendocrine tumours (NETs) and NET liver metastases (NETLMs) has not been defined. Methods: We identified 87 patients with NETs and 39 with NETLMs who had undergone resection. Immunohistochemistry was performed to determine TIL counts. Recurrence-free survival (RFS) and overall survival (OS) were determined using the log-rank test. Results: The median follow-up time was 62 months in NET patients and 48 months in NETLM patients. Vascular invasion and histologic grade were the only independent predictors of outcome for NETs and NETLMs, respectively. Analysis of intermediate-grade NETs indicated that a dense T cell (CD3+) infiltrate was associated with a median RFS of 128 months compared with 61 months for those with low levels of intratumoral T cells (P= 0.05, univariate analysis). Examination of NETLMs revealed that a low level of infiltrating regulatory T cells (Treg, FoxP3+) was a predictor of prolonged survival (P < 0.01, univariate analysis). Conclusions: A robust T cell infiltrate is associated with improved RFS following resection of intermediate-grade NETs, whereas the presence of more Treg correlated with shorter OS after treatment of NETLMs. Further study of the immune response to intermediate-grade NETs and NETLMs is warranted. © 2010 International Hepato-Pancreato-Biliary Association.

Duke Scholars

Published In

HPB

DOI

EISSN

1477-2574

ISSN

1365-182X

Publication Date

January 1, 2010

Volume

12

Issue

10

Start / End Page

674 / 683

Related Subject Headings

  • Surgery
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Katz, S. C., Donkor, C., Glasgow, K., Pillarisetty, V. G., Gönen, M., Espat, N. J., … Tang, L. H. (2010). T cell infiltrate and outcome following resection of intermediate-grade primary neuroendocrine tumours and liver metastases. HPB, 12(10), 674–683. https://doi.org/10.1111/j.1477-2574.2010.00231.x
Katz, S. C., C. Donkor, K. Glasgow, V. G. Pillarisetty, M. Gönen, N. J. Espat, D. S. Klimstra, et al. “T cell infiltrate and outcome following resection of intermediate-grade primary neuroendocrine tumours and liver metastases.” HPB 12, no. 10 (January 1, 2010): 674–83. https://doi.org/10.1111/j.1477-2574.2010.00231.x.
Katz SC, Donkor C, Glasgow K, Pillarisetty VG, Gönen M, Espat NJ, et al. T cell infiltrate and outcome following resection of intermediate-grade primary neuroendocrine tumours and liver metastases. HPB. 2010 Jan 1;12(10):674–83.
Katz, S. C., et al. “T cell infiltrate and outcome following resection of intermediate-grade primary neuroendocrine tumours and liver metastases.” HPB, vol. 12, no. 10, Jan. 2010, pp. 674–83. Scopus, doi:10.1111/j.1477-2574.2010.00231.x.
Katz SC, Donkor C, Glasgow K, Pillarisetty VG, Gönen M, Espat NJ, Klimstra DS, D’Angelica MI, Allen PJ, Jarnagin W, Dematteo RP, Brennan MF, Tang LH. T cell infiltrate and outcome following resection of intermediate-grade primary neuroendocrine tumours and liver metastases. HPB. 2010 Jan 1;12(10):674–683.
Journal cover image

Published In

HPB

DOI

EISSN

1477-2574

ISSN

1365-182X

Publication Date

January 1, 2010

Volume

12

Issue

10

Start / End Page

674 / 683

Related Subject Headings

  • Surgery
  • 3202 Clinical sciences
  • 1103 Clinical Sciences