Skip to main content

Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism.

Publication ,  Journal Article
Gupta, S; Ellis, SE; Ashar, FN; Moes, A; Bader, JS; Zhan, J; West, AB; Arking, DE
Published in: Nat Commun
December 10, 2014

Recent studies of genomic variation associated with autism have suggested the existence of extreme heterogeneity. Large-scale transcriptomics should complement these results to identify core molecular pathways underlying autism. Here we report results from a large-scale RNA sequencing effort, utilizing region-matched autism and control brains to identify neuronal and microglial genes robustly dysregulated in autism cortical brain. Remarkably, we note that a gene expression module corresponding to M2-activation states in microglia is negatively correlated with a differentially expressed neuronal module, implicating dysregulated microglial responses in concert with altered neuronal activity-dependent genes in autism brains. These observations provide pathways and candidate genes that highlight the interplay between innate immunity and neuronal activity in the aetiology of autism.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

December 10, 2014

Volume

5

Start / End Page

5748

Location

England
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gupta, S., Ellis, S. E., Ashar, F. N., Moes, A., Bader, J. S., Zhan, J., … Arking, D. E. (2014). Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism. Nat Commun, 5, 5748. https://doi.org/10.1038/ncomms6748
Gupta, Simone, Shannon E. Ellis, Foram N. Ashar, Anna Moes, Joel S. Bader, Jianan Zhan, Andrew B. West, and Dan E. Arking. “Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism.Nat Commun 5 (December 10, 2014): 5748. https://doi.org/10.1038/ncomms6748.
Gupta S, Ellis SE, Ashar FN, Moes A, Bader JS, Zhan J, et al. Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism. Nat Commun. 2014 Dec 10;5:5748.
Gupta, Simone, et al. “Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism.Nat Commun, vol. 5, Dec. 2014, p. 5748. Pubmed, doi:10.1038/ncomms6748.
Gupta S, Ellis SE, Ashar FN, Moes A, Bader JS, Zhan J, West AB, Arking DE. Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism. Nat Commun. 2014 Dec 10;5:5748.

Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

December 10, 2014

Volume

5

Start / End Page

5748

Location

England