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Antecedents of Obesity Among Children Born Extremely Preterm.

Publication ,  Journal Article
Wood, CT; Linthavong, O; Perrin, EM; Leviton, A; Allred, EN; Kuban, KCK; O'Shea, TM; ELGAN Study Investigators,
Published in: Pediatrics
November 2018

BACKGROUND: Childhood obesity is a pervasive public health problem with risk factors such as maternal prepregnancy BMI and rapid infant weight gain. Although catch-up weight gain promotes more favorable neurodevelopment among infants born preterm, it is not clear whether faster weight gain early in life, or other correlates of preterm birth, are associated with later obesity in this population. METHODS: We used prospective data from the multicenter, observational Extremely Low Gestational Age Newborn Study. Among 1506 eligible individuals in the initial cohort, 1198 were eligible for follow-up at 10 years of age. We examined BMI in 871 children (58% of the cohort; 74% of survivors) and analyzed relationships between antecedents and overweight or obesity at 10 years of age. A time-oriented approach to multinomial multivariable regression enabled us to calculate odds of overweight and obesity associated with pre- and postnatal antecedents. RESULTS: Prepregnancy maternal BMI ≥25 and top quartile infant weight gain in the first year were associated with increased risk of both overweight and obesity at 10 years of age. Single marital status was a risk factor for later child obesity and exposure to tobacco smoke was a risk factor for later child overweight. CONCLUSIONS: The risk profiles for overweight and obesity at 10 years of age among children born extremely preterm appear to be similar to the risk profiles of overweight and obesity among children born at term.

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Published In

Pediatrics

DOI

EISSN

1098-4275

Publication Date

November 2018

Volume

142

Issue

5

Location

United States

Related Subject Headings

  • Weight Gain
  • Risk Factors
  • Prospective Studies
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Pediatrics
  • Pediatric Obesity
  • Infant, Newborn
  • Infant, Extremely Premature
  • Infant
 

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Wood, C. T., Linthavong, O., Perrin, E. M., Leviton, A., Allred, E. N., Kuban, K. C. K., … ELGAN Study Investigators, . (2018). Antecedents of Obesity Among Children Born Extremely Preterm. Pediatrics, 142(5). https://doi.org/10.1542/peds.2018-0519
Wood, Charles T., Olivia Linthavong, Eliana M. Perrin, Alan Leviton, Elizabeth N. Allred, Karl C. K. Kuban, T Michael O’Shea, and T Michael ELGAN Study Investigators. “Antecedents of Obesity Among Children Born Extremely Preterm.Pediatrics 142, no. 5 (November 2018). https://doi.org/10.1542/peds.2018-0519.
Wood CT, Linthavong O, Perrin EM, Leviton A, Allred EN, Kuban KCK, et al. Antecedents of Obesity Among Children Born Extremely Preterm. Pediatrics. 2018 Nov;142(5).
Wood, Charles T., et al. “Antecedents of Obesity Among Children Born Extremely Preterm.Pediatrics, vol. 142, no. 5, Nov. 2018. Pubmed, doi:10.1542/peds.2018-0519.
Wood CT, Linthavong O, Perrin EM, Leviton A, Allred EN, Kuban KCK, O’Shea TM, ELGAN Study Investigators. Antecedents of Obesity Among Children Born Extremely Preterm. Pediatrics. 2018 Nov;142(5).

Published In

Pediatrics

DOI

EISSN

1098-4275

Publication Date

November 2018

Volume

142

Issue

5

Location

United States

Related Subject Headings

  • Weight Gain
  • Risk Factors
  • Prospective Studies
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Pediatrics
  • Pediatric Obesity
  • Infant, Newborn
  • Infant, Extremely Premature
  • Infant