Skip to main content

Converging pathways in neurodegeneration, from genetics to mechanisms.

Publication ,  Journal Article
Gan, L; Cookson, MR; Petrucelli, L; La Spada, AR
Published in: Nat Neurosci
October 2018

Neurodegenerative diseases cause progressive loss of cognitive and/or motor function and pose major challenges for societies with rapidly aging populations. Human genetics studies have shown that disease-causing rare mutations and risk-associated common alleles overlap in different neurodegenerative disorders. Here we review the intricate genotype-phenotype relationships and common cellular pathways emerging from recent genetic and mechanistic studies. Shared pathological mechanisms include defective protein quality-control and degradation pathways, dysfunctional mitochondrial homeostasis, stress granules, and maladaptive innate immune responses. Research efforts have started to bear fruit, as shown by recent treatment successes and an encouraging therapeutic outlook.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Nat Neurosci

DOI

EISSN

1546-1726

Publication Date

October 2018

Volume

21

Issue

10

Start / End Page

1300 / 1309

Location

United States

Related Subject Headings

  • Neurology & Neurosurgery
  • Neurodegenerative Diseases
  • Humans
  • Genetics
  • Genetic Predisposition to Disease
  • Animals
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
  • 1701 Psychology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gan, L., Cookson, M. R., Petrucelli, L., & La Spada, A. R. (2018). Converging pathways in neurodegeneration, from genetics to mechanisms. Nat Neurosci, 21(10), 1300–1309. https://doi.org/10.1038/s41593-018-0237-7
Gan, Li, Mark R. Cookson, Leonard Petrucelli, and Albert R. La Spada. “Converging pathways in neurodegeneration, from genetics to mechanisms.Nat Neurosci 21, no. 10 (October 2018): 1300–1309. https://doi.org/10.1038/s41593-018-0237-7.
Gan L, Cookson MR, Petrucelli L, La Spada AR. Converging pathways in neurodegeneration, from genetics to mechanisms. Nat Neurosci. 2018 Oct;21(10):1300–9.
Gan, Li, et al. “Converging pathways in neurodegeneration, from genetics to mechanisms.Nat Neurosci, vol. 21, no. 10, Oct. 2018, pp. 1300–09. Pubmed, doi:10.1038/s41593-018-0237-7.
Gan L, Cookson MR, Petrucelli L, La Spada AR. Converging pathways in neurodegeneration, from genetics to mechanisms. Nat Neurosci. 2018 Oct;21(10):1300–1309.

Published In

Nat Neurosci

DOI

EISSN

1546-1726

Publication Date

October 2018

Volume

21

Issue

10

Start / End Page

1300 / 1309

Location

United States

Related Subject Headings

  • Neurology & Neurosurgery
  • Neurodegenerative Diseases
  • Humans
  • Genetics
  • Genetic Predisposition to Disease
  • Animals
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
  • 1701 Psychology