Skip to main content
Journal cover image

Endoscopic injection of glutaraldehyde cross-linked collagen for the treatment of intrinsic sphincter deficiency in women.

Publication ,  Journal Article
Richardson, TD; Kennelly, MJ; Faerber, GJ
Published in: Urology
September 1995

OBJECTIVES: To determine the clinical efficacy, safety, and durability of endoscopically injected glutaraldehyde cross-linked (GAX) collagen for the treatment of intrinsic sphincter deficiency (ISD) in women. METHODS: Forty-two women with a mean age of 64 years (range, 28 to 88) underwent injection of GAX collagen for ISD. Collagen was injected via a transurethral or periurethral approach. Treatment outcome was based on the change in stress leak point pressures (SLPP) and individual incontinence grades before and after collagen injection. RESULTS: With a mean follow-up of 46 months (range, 10 to 66), 83% were cured (n = 17), greatly improved (n = 5), or improved (n = 13), and 17% were unchanged (n = 3) or worse (n = 4). The median number of treatments was 2 (range, 1 to 8). The 22 women greatly improved or cured required a mean of 2.4 collagen injection treatments, whereas the 20 women who were improved, unchanged, or worse had a mean of 4.1 treatments (P = 0.009). The mean amount of collagen injected per patient was 28.3 cc (range, 2.5 to 85). The group of women who were greatly improved or cured had a mean of 17.5 cc of collagen injected, whereas those who were improved, unchanged, or worse had a mean of 39.5 cc injected (P = 0.002). Mean pretreatment SLPPs of women improved, greatly improved, or cured versus the women unchanged or worse were not significantly different (P = 0.015). The 35 women who were improved or cured had a significant increase in mean SLPP of 65.4 cm H2O (P = 0.001) compared to a mean change in SLPP of 14.7 cm H2O in those women who were unchanged or worse (P = 0.038). CONCLUSIONS: GAX collagen injection for the treatment of stress urinary incontinence secondary to ISD appears to be safe, effective, and durable; hence, it should be considered the treatment of choice in appropriately selected female patients.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Urology

DOI

ISSN

0090-4295

Publication Date

September 1995

Volume

46

Issue

3

Start / End Page

378 / 381

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Urodynamics
  • Urinary Incontinence, Stress
  • Treatment Outcome
  • Middle Aged
  • Injections
  • Humans
  • Female
  • Endoscopy
  • Cystoscopy
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Richardson, T. D., Kennelly, M. J., & Faerber, G. J. (1995). Endoscopic injection of glutaraldehyde cross-linked collagen for the treatment of intrinsic sphincter deficiency in women. Urology, 46(3), 378–381. https://doi.org/10.1016/S0090-4295(99)80223-4
Richardson, T. D., M. J. Kennelly, and G. J. Faerber. “Endoscopic injection of glutaraldehyde cross-linked collagen for the treatment of intrinsic sphincter deficiency in women.Urology 46, no. 3 (September 1995): 378–81. https://doi.org/10.1016/S0090-4295(99)80223-4.
Richardson, T. D., et al. “Endoscopic injection of glutaraldehyde cross-linked collagen for the treatment of intrinsic sphincter deficiency in women.Urology, vol. 46, no. 3, Sept. 1995, pp. 378–81. Pubmed, doi:10.1016/S0090-4295(99)80223-4.
Journal cover image

Published In

Urology

DOI

ISSN

0090-4295

Publication Date

September 1995

Volume

46

Issue

3

Start / End Page

378 / 381

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Urodynamics
  • Urinary Incontinence, Stress
  • Treatment Outcome
  • Middle Aged
  • Injections
  • Humans
  • Female
  • Endoscopy
  • Cystoscopy