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Apoptotic cell-based therapies for promoting transplantation tolerance.

Publication ,  Journal Article
Dangi, A; Yu, S; Luo, X
Published in: Curr Opin Organ Transplant
October 2018

PURPOSE OF REVIEW: This article is aimed to provide readers with an updated review on the applicability, efficacy, and challenges of employing donor apoptotic cell-based therapies to promote transplantation tolerance in various experimental and clinical settings. RECENT FINDINGS: Recently, donor apoptotic cell-based therapies have been employed in various models of cell (including pancreatic islets and bone marrow hematopoietic stem cells) and solid organ (heart and kidney) transplantation to promote donor-specific tolerance. Published data, thus far, have revealed a high potential of this approach in inducing robust transplantation tolerance. Recent clinical trials have also underscored the safety and potential efficacy of this approach in alleviating graft-versus-host disease (GVHD) in bone marrow transplantation (BMT). Host factors including prior allo-sensitization and opportunistic infections pose major obstacles in establishing transplantation tolerance employing this strategy. However, emerging data provide strategies for overcoming such obstacles in these clinically relevant settings. SUMMARY: Donor apoptotic cell therapy is an emerging strategy in promoting transplantation tolerance, with recent data emphasizing its efficacy and applicability for transplantation tolerance in the clinic.

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Published In

Curr Opin Organ Transplant

DOI

EISSN

1531-7013

Publication Date

October 2018

Volume

23

Issue

5

Start / End Page

552 / 558

Location

United States

Related Subject Headings

  • Transplantation Tolerance
  • Surgery
  • Humans
  • Cell- and Tissue-Based Therapy
  • Apoptosis
  • 3204 Immunology
  • 3202 Clinical sciences
  • 1107 Immunology
  • 1103 Clinical Sciences
  • 0903 Biomedical Engineering
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Dangi, A., Yu, S., & Luo, X. (2018). Apoptotic cell-based therapies for promoting transplantation tolerance. Curr Opin Organ Transplant, 23(5), 552–558. https://doi.org/10.1097/MOT.0000000000000562
Dangi, Anil, Shuangjin Yu, and Xunrong Luo. “Apoptotic cell-based therapies for promoting transplantation tolerance.Curr Opin Organ Transplant 23, no. 5 (October 2018): 552–58. https://doi.org/10.1097/MOT.0000000000000562.
Dangi A, Yu S, Luo X. Apoptotic cell-based therapies for promoting transplantation tolerance. Curr Opin Organ Transplant. 2018 Oct;23(5):552–8.
Dangi, Anil, et al. “Apoptotic cell-based therapies for promoting transplantation tolerance.Curr Opin Organ Transplant, vol. 23, no. 5, Oct. 2018, pp. 552–58. Pubmed, doi:10.1097/MOT.0000000000000562.
Dangi A, Yu S, Luo X. Apoptotic cell-based therapies for promoting transplantation tolerance. Curr Opin Organ Transplant. 2018 Oct;23(5):552–558.

Published In

Curr Opin Organ Transplant

DOI

EISSN

1531-7013

Publication Date

October 2018

Volume

23

Issue

5

Start / End Page

552 / 558

Location

United States

Related Subject Headings

  • Transplantation Tolerance
  • Surgery
  • Humans
  • Cell- and Tissue-Based Therapy
  • Apoptosis
  • 3204 Immunology
  • 3202 Clinical sciences
  • 1107 Immunology
  • 1103 Clinical Sciences
  • 0903 Biomedical Engineering