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Early atherosclerosis is associated with retinal microvascular changes in adolescents with type 1 diabetes.

Publication ,  Journal Article
Peña, AS; Liew, G; Anderson, J; Giles, LC; Gent, R; Wong, TY; Couper, JJ
Published in: Pediatr Diabetes
December 2018

BACKGROUND/OBJECTIVE: Adolescents with type 1 diabetes have early macrovascular changes (increased intima-media thickness [IMT]) and early retinal changes that predict clinical disease in adulthood. We hypothesized that early changes in the macrovascular and retinal microvascular beds develop in parallel before retinopathy develops. We therefore aimed to investigate the relationship between changes in atherosclerosis (carotid and aortic IMT) and retinal vascular geometry cross-sectionally and longitudinally in adolescents with type 1 diabetes. METHODS: Ninety adolescents with type 1 diabetes (41 boys, aged 13.6 ± 3.5 years) who were enrolled in a randomized controlled trial had evaluations at baseline; 41 randomized to placebo were also investigated at 12 months for carotid and aortic IMT using ultrasound and retinal vascular geometry was measured from retinal photographs. RESULTS: There were significant associations between thicker mean/maximum carotid IMT and wider retinal arteriolar and venular calibers; for every 0.1 mm increase in mean carotid IMT, retinal arteriolar caliber increased by 7.90 μm (95% confidence interval [CI] 4.50, 11.30, P < 0.0001) and venular caliber by 9.61 μm (95% CI 4.16, 15.06, P = 0.0008). Increased mean aortic IMT was associated with increased arteriolar tortuosity (2.61, 95% CI 0.50, 4.71, P = 0.02). CONCLUSIONS: The early changes of atherosclerosis are associated with retinal microvascular changes in adolescents with type 1 diabetes. This supports parallel adverse changes in the macro and microvascular circulations from early adolescence in type 1 diabetes, and highlights the importance of early intervention.

Duke Scholars

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Published In

Pediatr Diabetes

DOI

EISSN

1399-5448

Publication Date

December 2018

Volume

19

Issue

8

Start / End Page

1467 / 1470

Location

Denmark

Related Subject Headings

  • Time Factors
  • Retinal Vessels
  • Retinal Diseases
  • Placebos
  • Metformin
  • Male
  • Longitudinal Studies
  • Humans
  • Female
  • Endocrinology & Metabolism
 

Citation

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Peña, A. S., Liew, G., Anderson, J., Giles, L. C., Gent, R., Wong, T. Y., & Couper, J. J. (2018). Early atherosclerosis is associated with retinal microvascular changes in adolescents with type 1 diabetes. Pediatr Diabetes, 19(8), 1467–1470. https://doi.org/10.1111/pedi.12764
Peña, Alexia S., Gerald Liew, Jemma Anderson, Lynne C. Giles, Roger Gent, Tien Y. Wong, and Jennifer J. Couper. “Early atherosclerosis is associated with retinal microvascular changes in adolescents with type 1 diabetes.Pediatr Diabetes 19, no. 8 (December 2018): 1467–70. https://doi.org/10.1111/pedi.12764.
Peña AS, Liew G, Anderson J, Giles LC, Gent R, Wong TY, et al. Early atherosclerosis is associated with retinal microvascular changes in adolescents with type 1 diabetes. Pediatr Diabetes. 2018 Dec;19(8):1467–70.
Peña, Alexia S., et al. “Early atherosclerosis is associated with retinal microvascular changes in adolescents with type 1 diabetes.Pediatr Diabetes, vol. 19, no. 8, Dec. 2018, pp. 1467–70. Pubmed, doi:10.1111/pedi.12764.
Peña AS, Liew G, Anderson J, Giles LC, Gent R, Wong TY, Couper JJ. Early atherosclerosis is associated with retinal microvascular changes in adolescents with type 1 diabetes. Pediatr Diabetes. 2018 Dec;19(8):1467–1470.
Journal cover image

Published In

Pediatr Diabetes

DOI

EISSN

1399-5448

Publication Date

December 2018

Volume

19

Issue

8

Start / End Page

1467 / 1470

Location

Denmark

Related Subject Headings

  • Time Factors
  • Retinal Vessels
  • Retinal Diseases
  • Placebos
  • Metformin
  • Male
  • Longitudinal Studies
  • Humans
  • Female
  • Endocrinology & Metabolism