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Oral Coadministration of an Intramuscular DNA/Modified Vaccinia Ankara Vaccine for Simian Immunodeficiency Virus Is Associated with Better Control of Infection in Orally Exposed Infant Macaques.

Publication ,  Journal Article
Curtis, AD; Walter, KA; Nabi, R; Jensen, K; Dwivedi, A; Pollara, J; Ferrari, G; Van Rompay, KKA; Amara, RR; Kozlowski, PA; De Paris, K
Published in: AIDS Res Hum Retroviruses
March 2019

The majority of human immunodeficiency virus (HIV) type 1 infections in infants are acquired orally through breastfeeding. Toward development of a pediatric HIV vaccine to prevent breastmilk transmission, we tested the efficacy of a simultaneous oral and intramuscular (IM) vaccination regimen for preventing oral simian immunodeficiency virus (SIV) transmission in infant rhesus macaques. Two groups of neonatal macaques were immunized with DNA encoding SIV virus-like particles (DNA-SIV) on weeks 0 and 3, then boosted with modified vaccinia Ankara (MVA) virus expressing SIV antigens (MVA-SIV) on weeks 6 and 9. One group was prime/boosted by the IM route only. Another group was immunized with DNA by both the IM and topical oral (O) buccal routes, and boosted with MVA-SIV by both the IM and sublingual (SL) routes. A third group of control animals received saline by O + IM routes on weeks 0 and 3, and empty MVA by SL + IM routes on weeks 6 and 9. On week 12, infants were orally challenged once weekly with SIVmac251 until infected. The vaccine regimen that included oral routes resulted in reduced peak viremia. The rate of infection acquisition in vaccinated infants was found to be associated with prechallenge intestinal immunoglobulin G (IgG) responses to SIV gp120 and V1V2. Peak viremia was inversely correlated with postinfection intestinal IgG responses to gp120, gp41, and V1V2. These results suggest that codelivery of a pediatric HIV vaccine by an oral route may be superior to IM-only regimens for generating mucosal antibodies and preventing HIV breastmilk transmission in neonates.

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Published In

AIDS Res Hum Retroviruses

DOI

EISSN

1931-8405

Publication Date

March 2019

Volume

35

Issue

3

Start / End Page

310 / 325

Location

United States

Related Subject Headings

  • Virology
  • Viremia
  • Viral Envelope Proteins
  • Vaccinia virus
  • Vaccination
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • SAIDS Vaccines
  • Mucous Membrane
 

Citation

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Curtis, A. D., Walter, K. A., Nabi, R., Jensen, K., Dwivedi, A., Pollara, J., … De Paris, K. (2019). Oral Coadministration of an Intramuscular DNA/Modified Vaccinia Ankara Vaccine for Simian Immunodeficiency Virus Is Associated with Better Control of Infection in Orally Exposed Infant Macaques. AIDS Res Hum Retroviruses, 35(3), 310–325. https://doi.org/10.1089/AID.2018.0180
Curtis, Alan D., Korey A. Walter, Rafiq Nabi, Kara Jensen, Aanini Dwivedi, Justin Pollara, Guido Ferrari, et al. “Oral Coadministration of an Intramuscular DNA/Modified Vaccinia Ankara Vaccine for Simian Immunodeficiency Virus Is Associated with Better Control of Infection in Orally Exposed Infant Macaques.AIDS Res Hum Retroviruses 35, no. 3 (March 2019): 310–25. https://doi.org/10.1089/AID.2018.0180.
Curtis, Alan D., et al. “Oral Coadministration of an Intramuscular DNA/Modified Vaccinia Ankara Vaccine for Simian Immunodeficiency Virus Is Associated with Better Control of Infection in Orally Exposed Infant Macaques.AIDS Res Hum Retroviruses, vol. 35, no. 3, Mar. 2019, pp. 310–25. Pubmed, doi:10.1089/AID.2018.0180.
Curtis AD, Walter KA, Nabi R, Jensen K, Dwivedi A, Pollara J, Ferrari G, Van Rompay KKA, Amara RR, Kozlowski PA, De Paris K. Oral Coadministration of an Intramuscular DNA/Modified Vaccinia Ankara Vaccine for Simian Immunodeficiency Virus Is Associated with Better Control of Infection in Orally Exposed Infant Macaques. AIDS Res Hum Retroviruses. 2019 Mar;35(3):310–325.
Journal cover image

Published In

AIDS Res Hum Retroviruses

DOI

EISSN

1931-8405

Publication Date

March 2019

Volume

35

Issue

3

Start / End Page

310 / 325

Location

United States

Related Subject Headings

  • Virology
  • Viremia
  • Viral Envelope Proteins
  • Vaccinia virus
  • Vaccination
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • SAIDS Vaccines
  • Mucous Membrane