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JCL roundtable: High-density lipoprotein function and reverse cholesterol transport.

Publication ,  Journal Article
Cuchel, M; Rohatgi, A; Sacks, FM; Guyton, JR
Published in: J Clin Lipidol
2018

High-density lipoproteins (HDL) have been known since the 1960s to be associated with protection from atherosclerotic cardiovascular disease. However, the mechanisms of this protection are unclear. The extent to which HDL per se vs other correlated metabolic factors may mitigate atherosclerosis has been seriously questioned. In fact, new epidemiologic studies have found that in some clinical settings, very high HDL cholesterol levels correlate with increased atherosclerotic risk. Most importantly, over the past 2 decades, randomized clinical trials targeting HDL have failed to reproduce the usual epidemiologic inverse relation of HDL cholesterol to atherosclerotic events. In this roundtable discussion, we bring together 3 expert investigators working in the HDL field to elucidate questions of HDL function. One area of agreement is that reverse cholesterol transport remains a primary hypothesis for an anti-atherogenic role of HDL. Bioassays that measure cholesterol efflux capacity of HDL (or of apolipoprotein [apo] B-depleted plasma) have emerged as potentially accurate surrogates for reverse cholesterol transport. ApoA-I is the major functional apoprotein of HDL, but apoE- and apoC-III-containing subpopulations of HDL may have significant roles. Anti- and pro-inflammatory functions of various HDL particles, as well as the role of oxidative and other modifications, are gaining attention.

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Published In

J Clin Lipidol

DOI

ISSN

1933-2874

Publication Date

2018

Volume

12

Issue

5

Start / End Page

1086 / 1094

Location

United States

Related Subject Headings

  • Risk Factors
  • Lipoproteins, HDL
  • Humans
  • Cholesterol
  • Cardiovascular System & Hematology
  • Biological Transport
  • Atherosclerosis
  • 3205 Medical biochemistry and metabolomics
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

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Cuchel, M., Rohatgi, A., Sacks, F. M., & Guyton, J. R. (2018). JCL roundtable: High-density lipoprotein function and reverse cholesterol transport. J Clin Lipidol, 12(5), 1086–1094. https://doi.org/10.1016/j.jacl.2018.09.005
Cuchel, Marina, Anand Rohatgi, Frank M. Sacks, and John R. Guyton. “JCL roundtable: High-density lipoprotein function and reverse cholesterol transport.J Clin Lipidol 12, no. 5 (2018): 1086–94. https://doi.org/10.1016/j.jacl.2018.09.005.
Cuchel M, Rohatgi A, Sacks FM, Guyton JR. JCL roundtable: High-density lipoprotein function and reverse cholesterol transport. J Clin Lipidol. 2018;12(5):1086–94.
Cuchel, Marina, et al. “JCL roundtable: High-density lipoprotein function and reverse cholesterol transport.J Clin Lipidol, vol. 12, no. 5, 2018, pp. 1086–94. Pubmed, doi:10.1016/j.jacl.2018.09.005.
Cuchel M, Rohatgi A, Sacks FM, Guyton JR. JCL roundtable: High-density lipoprotein function and reverse cholesterol transport. J Clin Lipidol. 2018;12(5):1086–1094.
Journal cover image

Published In

J Clin Lipidol

DOI

ISSN

1933-2874

Publication Date

2018

Volume

12

Issue

5

Start / End Page

1086 / 1094

Location

United States

Related Subject Headings

  • Risk Factors
  • Lipoproteins, HDL
  • Humans
  • Cholesterol
  • Cardiovascular System & Hematology
  • Biological Transport
  • Atherosclerosis
  • 3205 Medical biochemistry and metabolomics
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology