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Working Toward an Improved Understanding of Chronic Cardiorenal Syndrome Type 4.

Publication ,  Journal Article
Edmonston, D; Morris, JD; Middleton, JP
Published in: Adv Chronic Kidney Dis
September 2018

Chronic diseases of the heart and of the kidneys commonly coexist in individuals. Certainly combined and persistent heart and kidney failure can arise from a common pathologic insult, for example, as a consequence of poorly controlled hypertension or of severe diffuse arterial disease. However, strong evidence is emerging to suggest that cross talk exists between the heart and the kidney. Independent processes are set in motion when kidney function is chronically diminished, and these processes can have distinct adverse effects on the heart. The complex chronic heart condition that results from chronic kidney disease (CKD) has been termed cardiorenal syndrome type 4. This review will include an updated description of the cardiac morphology in patients who have CKD, an overview of the most likely CKD-sourced culprits for these cardiac changes, and the potential therapeutic strategies to limit cardiac complications in patients who have CKD.

Duke Scholars

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Published In

Adv Chronic Kidney Dis

DOI

EISSN

1548-5609

Publication Date

September 2018

Volume

25

Issue

5

Start / End Page

454 / 467

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Survival Analysis
  • Risk Assessment
  • Renal Insufficiency, Chronic
  • Prognosis
  • Male
  • Kidney Function Tests
  • Humans
  • Heart Function Tests
  • Heart Failure
 

Citation

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Edmonston, D., Morris, J. D., & Middleton, J. P. (2018). Working Toward an Improved Understanding of Chronic Cardiorenal Syndrome Type 4. Adv Chronic Kidney Dis, 25(5), 454–467. https://doi.org/10.1053/j.ackd.2018.08.010
Edmonston, Daniel, Jessica D. Morris, and John P. Middleton. “Working Toward an Improved Understanding of Chronic Cardiorenal Syndrome Type 4.Adv Chronic Kidney Dis 25, no. 5 (September 2018): 454–67. https://doi.org/10.1053/j.ackd.2018.08.010.
Edmonston D, Morris JD, Middleton JP. Working Toward an Improved Understanding of Chronic Cardiorenal Syndrome Type 4. Adv Chronic Kidney Dis. 2018 Sep;25(5):454–67.
Edmonston, Daniel, et al. “Working Toward an Improved Understanding of Chronic Cardiorenal Syndrome Type 4.Adv Chronic Kidney Dis, vol. 25, no. 5, Sept. 2018, pp. 454–67. Pubmed, doi:10.1053/j.ackd.2018.08.010.
Edmonston D, Morris JD, Middleton JP. Working Toward an Improved Understanding of Chronic Cardiorenal Syndrome Type 4. Adv Chronic Kidney Dis. 2018 Sep;25(5):454–467.
Journal cover image

Published In

Adv Chronic Kidney Dis

DOI

EISSN

1548-5609

Publication Date

September 2018

Volume

25

Issue

5

Start / End Page

454 / 467

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Survival Analysis
  • Risk Assessment
  • Renal Insufficiency, Chronic
  • Prognosis
  • Male
  • Kidney Function Tests
  • Humans
  • Heart Function Tests
  • Heart Failure