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Multicomorbidity of chronic diseases and substance use disorders and their association with hospitalization: Results from electronic health records data.

Publication ,  Journal Article
Wu, L-T; Zhu, H; Ghitza, UE
Published in: Drug Alcohol Depend
November 1, 2018

BACKGROUND: Chronic diseases are prevalent and the leading causes of mortality. Comorbidity of substance use disorders (SUDs) and chronic diseases is understudied to inform behavioral healthcare integration. OBJECTIVES: This study leveraged electronic health record (EHR) data of 211,880 adults from a large health system to examine prevalence and correlates of comorbidity of SUDs and nine chronic disease groups and to determine their association with hospitalization. METHODS: Logistic regression analyses were conducted to estimate associations between chronic diseases and SUDs. To control for severity of diagnosis, analyses of associations between SUD and hospitalization were stratified by the number of chronic conditions. RESULTS: In the sample, 48.3% had ≥1 chronic condition (hypertension 33.7%, arthritis 16.2%, diabetes 13.7%, chronic kidney disease 9.9%, asthma 9.1%, chronic obstructive pulmonary disease 8.9%, ischemic heart disease 8.3%, cancer 4.6%, and hepatitis 1.3%). Prevalence of SUD (overall 13.3%) among patients increased with multiple chronic conditions (14.3% having SUD among patients with one condition; 21.2% having SUD among patients with two to three conditions; and 32.5% having SUD among patients with 4-9 conditions). Chronic conditions were associated with increased odds of SUDs. For all SUD groups, hospitalization was more prevalent among patients with SUD than those without it; prevalence of hospitalization increased with the number of comorbid chronic conditions. CONCLUSIONS: Findings reveal a striking pattern of multicomorbidity of SUD and chronic diseases and its positive association with hospitalization. Behavioral healthcare integration should consider efforts to assess and treat comorbid SUD and chronic diseases, especially among adults with multiple chronic conditions.

Duke Scholars

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Published In

Drug Alcohol Depend

DOI

EISSN

1879-0046

Publication Date

November 1, 2018

Volume

192

Start / End Page

316 / 323

Location

Ireland

Related Subject Headings

  • Young Adult
  • Substance-Related Disorders
  • Substance Abuse
  • Prevalence
  • Neoplasms
  • Middle Aged
  • Male
  • Humans
  • Hospitalization
  • Heart Diseases
 

Citation

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Chicago
ICMJE
MLA
NLM
Wu, L.-T., Zhu, H., & Ghitza, U. E. (2018). Multicomorbidity of chronic diseases and substance use disorders and their association with hospitalization: Results from electronic health records data. Drug Alcohol Depend, 192, 316–323. https://doi.org/10.1016/j.drugalcdep.2018.08.013
Wu, Li-Tzy, He Zhu, and Udi E. Ghitza. “Multicomorbidity of chronic diseases and substance use disorders and their association with hospitalization: Results from electronic health records data.Drug Alcohol Depend 192 (November 1, 2018): 316–23. https://doi.org/10.1016/j.drugalcdep.2018.08.013.
Wu, Li-Tzy, et al. “Multicomorbidity of chronic diseases and substance use disorders and their association with hospitalization: Results from electronic health records data.Drug Alcohol Depend, vol. 192, Nov. 2018, pp. 316–23. Pubmed, doi:10.1016/j.drugalcdep.2018.08.013.
Journal cover image

Published In

Drug Alcohol Depend

DOI

EISSN

1879-0046

Publication Date

November 1, 2018

Volume

192

Start / End Page

316 / 323

Location

Ireland

Related Subject Headings

  • Young Adult
  • Substance-Related Disorders
  • Substance Abuse
  • Prevalence
  • Neoplasms
  • Middle Aged
  • Male
  • Humans
  • Hospitalization
  • Heart Diseases