Skip to main content
Journal cover image
Cell Surface GRP78, a New Paradigm in Signal Transduction Biology

An Historical Perspective: Cell Surface GRP78, a New Paradigm in Signal Transduction Biology

Publication ,  Chapter
Pizzo, SV
January 1, 2018

This chapter will present a historical perspective with respect to the presence of Glucose Regulated Protein 78,000 (GRP78) on the cell surface. Its presence there was completely unexpected since this protein normally functions as a molecular chaperone within the endoplasmic reticulum. When it appears on the cell surface, most particularly of cancer cells, it functions as a cell surface receptor coupled to signaling cascades which are pro-proliferative, antiapoptotic, and promigratory. Studies have identified antibodies in the plasma of cancer patients which bind to the amino-terminal domain of GRP78 where natural ligands also bind, functioning as agonistics. These antibodies are markers suggesting a poor prognosis. By contrast, antibodies which bind to the carboxyl-terminal domain block cancer cell proliferation and migration while promoting apoptosis. Thus, cell surface-associated GRP78 offers a new target for cancer therapy, particularly employing monoclonal antibodies.

Duke Scholars

DOI

ISBN

9780128123522

Publication Date

January 1, 2018

Start / End Page

1 / 7
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Pizzo, S. V. (2018). An Historical Perspective: Cell Surface GRP78, a New Paradigm in Signal Transduction Biology. In Cell Surface GRP78, a New Paradigm in Signal Transduction Biology (pp. 1–7). https://doi.org/10.1016/B978-0-12-812351-5.00001-5
Pizzo, S. V. “An Historical Perspective: Cell Surface GRP78, a New Paradigm in Signal Transduction Biology.” In Cell Surface GRP78, a New Paradigm in Signal Transduction Biology, 1–7, 2018. https://doi.org/10.1016/B978-0-12-812351-5.00001-5.
Pizzo SV. An Historical Perspective: Cell Surface GRP78, a New Paradigm in Signal Transduction Biology. In: Cell Surface GRP78, a New Paradigm in Signal Transduction Biology. 2018. p. 1–7.
Pizzo, S. V. “An Historical Perspective: Cell Surface GRP78, a New Paradigm in Signal Transduction Biology.” Cell Surface GRP78, a New Paradigm in Signal Transduction Biology, 2018, pp. 1–7. Scopus, doi:10.1016/B978-0-12-812351-5.00001-5.
Pizzo SV. An Historical Perspective: Cell Surface GRP78, a New Paradigm in Signal Transduction Biology. Cell Surface GRP78, a New Paradigm in Signal Transduction Biology. 2018. p. 1–7.
Journal cover image

DOI

ISBN

9780128123522

Publication Date

January 1, 2018

Start / End Page

1 / 7