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Antimicrobial Resistance in Neisseria gonorrhoeae: Proceedings of the STAR Sexually Transmitted Infection-Clinical Trial Group Programmatic Meeting.

Publication ,  Journal Article
Cristillo, AD; Bristow, CC; Torrone, E; Dillon, J-A; Kirkcaldy, RD; Dong, H; Grad, YH; Nicholas, RA; Rice, PA; Lawrence, K; Oldach, D; Zhou, P ...
Published in: Sex Transm Dis
March 2019

The goal of the Sexually Transmitted Infection Clinical Trial Group's Antimicrobial Resistance (AMR) in Neisseria gonorrhoeae (NG) meeting was to assemble experts from academia, government, nonprofit and industry to discuss the current state of research, gaps and challenges in research and technology and priorities and new directions to address the continued emergence of multidrug-resistant NG infections. Topics discussed at the meeting, which will be the focus of this article, include AMR NG global surveillance initiatives, the use of whole genome sequencing and bioinformatics to understand mutations associated with AMR, mechanisms of AMR, and novel antibiotics, vaccines and other methods to treat AMR NG. Key points highlighted during the meeting include: (i) US and International surveillance programs to understand AMR in NG; (ii) the US National Strategy for combating antimicrobial-resistant bacteria; (iii) surveillance needs, challenges, and novel technologies; (iv) plasmid-mediated and chromosomally mediated mechanisms of AMR in NG; (v) novel therapeutic (eg, sialic acid analogs, factor H [FH]/Fc fusion molecule, monoclonal antibodies, topoisomerase inhibitors, fluoroketolides, LpxC inhibitors) and preventative (eg, peptide mimic) strategies to combat infection. The way forward will require renewed political will, new funding initiatives, and collaborations across academic and commercial research and public health programs.

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Published In

Sex Transm Dis

DOI

EISSN

1537-4521

Publication Date

March 2019

Volume

46

Issue

3

Start / End Page

e18 / e25

Location

United States

Related Subject Headings

  • World Health Organization
  • Triazoles
  • Topoisomerase Inhibitors
  • Spiro Compounds
  • Sexually Transmitted Diseases
  • Public Health
  • Public Health
  • Oxazolidinones
  • Neisseria gonorrhoeae
  • Mutation
 

Citation

APA
Chicago
ICMJE
MLA
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Cristillo, A. D., Bristow, C. C., Torrone, E., Dillon, J.-A., Kirkcaldy, R. D., Dong, H., … Klausner, J. D. (2019). Antimicrobial Resistance in Neisseria gonorrhoeae: Proceedings of the STAR Sexually Transmitted Infection-Clinical Trial Group Programmatic Meeting. Sex Transm Dis, 46(3), e18–e25. https://doi.org/10.1097/OLQ.0000000000000929
Cristillo, Anthony D., Claire C. Bristow, Elizabeth Torrone, Jo-Anne Dillon, Robert D. Kirkcaldy, Huan Dong, Yonatan H. Grad, et al. “Antimicrobial Resistance in Neisseria gonorrhoeae: Proceedings of the STAR Sexually Transmitted Infection-Clinical Trial Group Programmatic Meeting.Sex Transm Dis 46, no. 3 (March 2019): e18–25. https://doi.org/10.1097/OLQ.0000000000000929.
Cristillo AD, Bristow CC, Torrone E, Dillon J-A, Kirkcaldy RD, Dong H, et al. Antimicrobial Resistance in Neisseria gonorrhoeae: Proceedings of the STAR Sexually Transmitted Infection-Clinical Trial Group Programmatic Meeting. Sex Transm Dis. 2019 Mar;46(3):e18–25.
Cristillo, Anthony D., et al. “Antimicrobial Resistance in Neisseria gonorrhoeae: Proceedings of the STAR Sexually Transmitted Infection-Clinical Trial Group Programmatic Meeting.Sex Transm Dis, vol. 46, no. 3, Mar. 2019, pp. e18–25. Pubmed, doi:10.1097/OLQ.0000000000000929.
Cristillo AD, Bristow CC, Torrone E, Dillon J-A, Kirkcaldy RD, Dong H, Grad YH, Nicholas RA, Rice PA, Lawrence K, Oldach D, Shafer WM, Zhou P, Wi TE, Morris SR, Klausner JD. Antimicrobial Resistance in Neisseria gonorrhoeae: Proceedings of the STAR Sexually Transmitted Infection-Clinical Trial Group Programmatic Meeting. Sex Transm Dis. 2019 Mar;46(3):e18–e25.

Published In

Sex Transm Dis

DOI

EISSN

1537-4521

Publication Date

March 2019

Volume

46

Issue

3

Start / End Page

e18 / e25

Location

United States

Related Subject Headings

  • World Health Organization
  • Triazoles
  • Topoisomerase Inhibitors
  • Spiro Compounds
  • Sexually Transmitted Diseases
  • Public Health
  • Public Health
  • Oxazolidinones
  • Neisseria gonorrhoeae
  • Mutation