Immune Tolerance for Autoimmune Disease and Cell Transplantation.
The undesired destruction of healthy cells, either endogenous or transplanted, by the immune system results in the loss of tissue function or limits strategies to restore tissue function. Current therapies typically involve nonspecific immunosuppression that may prevent the appropriate response to an antigen, thereby decreasing humoral immunity and increasing the risks of patient susceptibility to opportunistic infections, viral reactivation, and neoplasia. The induction of antigen-specific immunological tolerance to block undesired immune responses to self- or allogeneic antigens, while maintaining the integrity of the remaining immune system, has the potential to transform the current treatment of autoimmune disease and serve as a key enabling technology for therapies based on cell transplantation.
Duke Scholars
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Related Subject Headings
- Treatment Outcome
- Models, Immunological
- Immunosuppression Therapy
- Immune Tolerance
- Humans
- Evidence-Based Medicine
- Cell Transplantation
- Biomedical Engineering
- Autoimmune Diseases
- Animals
Citation
Published In
DOI
EISSN
Publication Date
Volume
Start / End Page
Location
Related Subject Headings
- Treatment Outcome
- Models, Immunological
- Immunosuppression Therapy
- Immune Tolerance
- Humans
- Evidence-Based Medicine
- Cell Transplantation
- Biomedical Engineering
- Autoimmune Diseases
- Animals