Comparative genomic evidence for the involvement of schizophrenia risk genes in antipsychotic effects.
Genome-wide association studies (GWAS) for schizophrenia have identified over 100 loci encoding >500 genes. It is unclear whether any of these genes, other than dopamine receptor D2, are immediately relevant to antipsychotic effects or represent novel antipsychotic targets. We applied an in vivo molecular approach to this question by performing RNA sequencing of brain tissue from mice chronically treated with the antipsychotic haloperidol or vehicle. We observed significant enrichments of haloperidol-regulated genes in schizophrenia GWAS loci and in schizophrenia-associated biological pathways. Our findings provide empirical support for overlap between genetic variation underlying the pathophysiology of schizophrenia and the molecular effects of a prototypical antipsychotic.
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- Sequence Analysis, RNA
- Schizophrenic Psychology
- Schizophrenia
- Risk Factors
- Psychiatry
- Mice, Inbred C57BL
- Mice
- Male
- Haloperidol
- Genomics
Citation
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Sequence Analysis, RNA
- Schizophrenic Psychology
- Schizophrenia
- Risk Factors
- Psychiatry
- Mice, Inbred C57BL
- Mice
- Male
- Haloperidol
- Genomics