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Environment matters: microglia function and dysfunction in a changing world.

Publication ,  Journal Article
Hanamsagar, R; Bilbo, SD
Published in: Current opinion in neurobiology
December 2017

The immune system is our interface with the environment, and immune molecules such as cytokines and chemokines and the cells that produce them within the brain, notably microglia, are critical for normal brain development. This recognition has in recent years led to the working hypothesis that inflammatory events during pregnancy or the early postnatal period, for example, in response to infection, may disrupt the normal developmental trajectory of microglia and consequently their interactions with neurons, thereby contributing to the risk for neurological disorders. The current article outlines recent findings on the impact of diverse, pervasive environmental challenges, beyond infection, including air pollution and maternal stress; and their impact on microglial development and its broad implications for neural pathologies.

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Published In

Current opinion in neurobiology

DOI

EISSN

1873-6882

ISSN

0959-4388

Publication Date

December 2017

Volume

47

Start / End Page

146 / 155

Related Subject Headings

  • Prenatal Exposure Delayed Effects
  • Pregnancy Complications
  • Pregnancy
  • Microglia
  • Humans
  • Female
  • Environmental Exposure
  • Brain
  • Animals
  • 3209 Neurosciences
 

Citation

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Hanamsagar, R., & Bilbo, S. D. (2017). Environment matters: microglia function and dysfunction in a changing world. Current Opinion in Neurobiology, 47, 146–155. https://doi.org/10.1016/j.conb.2017.10.007
Hanamsagar, Richa, and Staci D. Bilbo. “Environment matters: microglia function and dysfunction in a changing world.Current Opinion in Neurobiology 47 (December 2017): 146–55. https://doi.org/10.1016/j.conb.2017.10.007.
Hanamsagar R, Bilbo SD. Environment matters: microglia function and dysfunction in a changing world. Current opinion in neurobiology. 2017 Dec;47:146–55.
Hanamsagar, Richa, and Staci D. Bilbo. “Environment matters: microglia function and dysfunction in a changing world.Current Opinion in Neurobiology, vol. 47, Dec. 2017, pp. 146–55. Epmc, doi:10.1016/j.conb.2017.10.007.
Hanamsagar R, Bilbo SD. Environment matters: microglia function and dysfunction in a changing world. Current opinion in neurobiology. 2017 Dec;47:146–155.
Journal cover image

Published In

Current opinion in neurobiology

DOI

EISSN

1873-6882

ISSN

0959-4388

Publication Date

December 2017

Volume

47

Start / End Page

146 / 155

Related Subject Headings

  • Prenatal Exposure Delayed Effects
  • Pregnancy Complications
  • Pregnancy
  • Microglia
  • Humans
  • Female
  • Environmental Exposure
  • Brain
  • Animals
  • 3209 Neurosciences