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Genetic and psychological factors interact to predict physical impairment phenotypes following exercise-induced shoulder injury.

Publication ,  Journal Article
Borsa, PA; Parr, JJ; Wallace, MR; Wu, SS; Dai, Y; Fillingim, RB; George, SZ
Published in: J Pain Res
2018

BACKGROUND: We investigated interactions between genetic and psychological factors in predicting shoulder impairment phenotypes. We hypothesized that pro-inflammatory genes would display stronger relationships compared with pain-related genes when combined with psychological factors for predicting phenotypic changes. SUBJECTS AND METHODS: Altogether, 190 participants completed a 5-day experimental protocol. An experimental shoulder injury model was used to induce physical impairment, and a priori selected genetic (pain-related, pro-inflammatory) and psychological (anxiety, depressive symptoms, pain catastrophizing, fear of pain, kinesiophobia) factors were included as predictors of interest. Impairment phenotypes were injury-induced deficits in range of motion (ROM) and strength. After controlling for age, sex, and race, genetic and psychological predictors were entered separately as main effects and interaction terms in regression models for each phenotype. RESULTS: Strong statistical evidence was provided for interactions between: 1) IL-1β (rs1143634) and fear of pain for predicting loss of shoulder flexion and abduction, 2) IL-1β (rs1143634) and anxiety for predicting loss of flexion, and 3) IL-1β (rs1143634) and depressive symptoms for predicting loss of internal rotation. In addition, the interaction between OPRM1 (rs1799971) and fear of pain as well as COMT (rs4818) and pain catastrophizing provided strong statistical evidence for predicting strength loss. CONCLUSION: Pro-inflammatory gene variants contributed more to physical impairment with two single nucleotide polymorphisms (SNPs; IL-1β [rs1143634] and TNF/LTA [rs2229094]) interacting with psychological factors to predict six shoulder impairment phenotypes. In comparison, two pain-related gene SNPs (OPRM1 [rs1799971] and COMT [rs4818]) interacted with psychological factors to predict four shoulder impairment phenotypes (abduction: 5-day average loss; strength loss: 5-day average, peak, and relative loss).

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Published In

J Pain Res

DOI

ISSN

1178-7090

Publication Date

2018

Volume

11

Start / End Page

2497 / 2508

Location

New Zealand

Related Subject Headings

  • 3214 Pharmacology and pharmaceutical sciences
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences
  • 1103 Clinical Sciences
 

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Borsa, P. A., Parr, J. J., Wallace, M. R., Wu, S. S., Dai, Y., Fillingim, R. B., & George, S. Z. (2018). Genetic and psychological factors interact to predict physical impairment phenotypes following exercise-induced shoulder injury. J Pain Res, 11, 2497–2508. https://doi.org/10.2147/JPR.S171498
Borsa, Paul A., Jeffrey J. Parr, Margaret R. Wallace, Samuel S. Wu, Yunfeng Dai, Roger B. Fillingim, and Steven Z. George. “Genetic and psychological factors interact to predict physical impairment phenotypes following exercise-induced shoulder injury.J Pain Res 11 (2018): 2497–2508. https://doi.org/10.2147/JPR.S171498.
Borsa PA, Parr JJ, Wallace MR, Wu SS, Dai Y, Fillingim RB, et al. Genetic and psychological factors interact to predict physical impairment phenotypes following exercise-induced shoulder injury. J Pain Res. 2018;11:2497–508.
Borsa, Paul A., et al. “Genetic and psychological factors interact to predict physical impairment phenotypes following exercise-induced shoulder injury.J Pain Res, vol. 11, 2018, pp. 2497–508. Pubmed, doi:10.2147/JPR.S171498.
Borsa PA, Parr JJ, Wallace MR, Wu SS, Dai Y, Fillingim RB, George SZ. Genetic and psychological factors interact to predict physical impairment phenotypes following exercise-induced shoulder injury. J Pain Res. 2018;11:2497–2508.

Published In

J Pain Res

DOI

ISSN

1178-7090

Publication Date

2018

Volume

11

Start / End Page

2497 / 2508

Location

New Zealand

Related Subject Headings

  • 3214 Pharmacology and pharmaceutical sciences
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences
  • 1103 Clinical Sciences