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Contribution of Baroreceptor Function to Pain Perception and Perioperative Outcomes.

Publication ,  Journal Article
Suarez-Roca, H; Klinger, RY; Podgoreanu, MV; Ji, R-R; Sigurdsson, MI; Waldron, N; Mathew, JP; Maixner, W
Published in: Anesthesiology
April 2019

Baroreceptors are mechanosensitive elements of the peripheral nervous system that maintain homeostasis by coordinating physiologic responses to external and internal stimuli. While it is recognized that carotid and cardiopulmonary baroreceptor reflexes modulate autonomic output to mitigate excessive fluctuations in arterial blood pressure and to maintain intravascular volume, increasing evidence suggests that baroreflex pathways also project to key regions of the central nervous system that regulate somatosensory, somatomotor, and central nervous system arousal. In addition to maintaining autonomic homeostasis, baroreceptor activity modulates the perception of pain, as well as neuroimmune, neuroendocrine, and cognitive responses to physical and psychologic stressors. This review summarizes the role that baroreceptor pathways play in modulating acute and chronic pain perception. The contribution of baroreceptor function to postoperative outcomes is also presented. Finally, methods that enhance baroreceptor function, which hold promise in improving postoperative and pain management outcomes, are presented.

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Published In

Anesthesiology

DOI

EISSN

1528-1175

Publication Date

April 2019

Volume

130

Issue

4

Start / End Page

634 / 650

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Pressoreceptors
  • Postoperative Complications
  • Pain Perception
  • Pain
  • Humans
  • Baroreflex
  • Animals
  • Anesthesiology
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Suarez-Roca, H., Klinger, R. Y., Podgoreanu, M. V., Ji, R.-R., Sigurdsson, M. I., Waldron, N., … Maixner, W. (2019). Contribution of Baroreceptor Function to Pain Perception and Perioperative Outcomes. Anesthesiology, 130(4), 634–650. https://doi.org/10.1097/ALN.0000000000002510
Suarez-Roca, Heberto, Rebecca Y. Klinger, Mihai V. Podgoreanu, Ru-Rong Ji, Martin I. Sigurdsson, Nathan Waldron, Joseph P. Mathew, and William Maixner. “Contribution of Baroreceptor Function to Pain Perception and Perioperative Outcomes.Anesthesiology 130, no. 4 (April 2019): 634–50. https://doi.org/10.1097/ALN.0000000000002510.
Suarez-Roca H, Klinger RY, Podgoreanu MV, Ji R-R, Sigurdsson MI, Waldron N, et al. Contribution of Baroreceptor Function to Pain Perception and Perioperative Outcomes. Anesthesiology. 2019 Apr;130(4):634–50.
Suarez-Roca, Heberto, et al. “Contribution of Baroreceptor Function to Pain Perception and Perioperative Outcomes.Anesthesiology, vol. 130, no. 4, Apr. 2019, pp. 634–50. Pubmed, doi:10.1097/ALN.0000000000002510.
Suarez-Roca H, Klinger RY, Podgoreanu MV, Ji R-R, Sigurdsson MI, Waldron N, Mathew JP, Maixner W. Contribution of Baroreceptor Function to Pain Perception and Perioperative Outcomes. Anesthesiology. 2019 Apr;130(4):634–650.

Published In

Anesthesiology

DOI

EISSN

1528-1175

Publication Date

April 2019

Volume

130

Issue

4

Start / End Page

634 / 650

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Pressoreceptors
  • Postoperative Complications
  • Pain Perception
  • Pain
  • Humans
  • Baroreflex
  • Animals
  • Anesthesiology
  • 3202 Clinical sciences