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NCCN Guidelines as a Model of Extended Criteria for Lung Cancer Screening.

Publication ,  Journal Article
McKee, BJ; Regis, S; Borondy-Kitts, AK; Hashim, JA; French, RJ; Wald, C; McKee, AB
Published in: J Natl Compr Canc Netw
April 2018

Background: This review assessed the performance of patients in NCCN high-risk group 2 in a clinical CT lung screening (CTLS) program. Methods: We retrospectively reviewed screening results for all patients from our institution undergoing clinical CTLS from January 2012 through December 2016, with follow-up through June 2017. To qualify for screening, patients had to meet the NCCN Guidelines high-risk criteria for CTLS, have a physician order for screening, be asymptomatic, be lung cancer-free for 5 years, and have no known metastatic disease. We compared demographics and screening performance of NCCN high-risk groups 1 and 2 across >4 rounds of screening. Screening metrics assessed included rates of positive and suspicious examinations, significant incidental and infectious/inflammatory findings, false negatives, and cancer detection. We also compared cancer stage and histology detected in each NCCN high-risk group. Results: A total of 2,927 individuals underwent baseline screening, of which 698 (24%) were in NCCN group 2. On average, group 2 patients were younger (60.6 vs 63.1 years), smoked less (38.8 vs 50.8 pack-years), had quit longer (18.1 vs 6.3 years), and were more often former smokers (61.4% vs 44.2%). Positive and suspicious examination rates, false negatives, and rates of infectious/inflammatory findings were equivalent in groups 1 and 2 across all rounds of screening. An increased rate of cancer detection was observed in group 2 during the second annual (T2) screening round (2.7% vs 0.5%; P=.005), with no difference in the other screening rounds: baseline (T0; 2% vs 2.3%; P=.61), first annual (T1; 1.2% vs 1.7%; P=.41), and third annual and beyond (≥T3; 1.2% vs 1.1%; P=1.00). Conclusions: CTLS appears to be equally effective in both NCCN high-risk groups.

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Published In

J Natl Compr Canc Netw

DOI

EISSN

1540-1413

Publication Date

April 2018

Volume

16

Issue

4

Start / End Page

444 / 449

Location

United States

Related Subject Headings

  • Risk Factors
  • Retrospective Studies
  • Radiography
  • Practice Guidelines as Topic
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Mass Screening
  • Lung Neoplasms
  • Humans
  • Early Detection of Cancer
 

Citation

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McKee, B. J., Regis, S., Borondy-Kitts, A. K., Hashim, J. A., French, R. J., Wald, C., & McKee, A. B. (2018). NCCN Guidelines as a Model of Extended Criteria for Lung Cancer Screening. J Natl Compr Canc Netw, 16(4), 444–449. https://doi.org/10.6004/jnccn.2018.7021
McKee, Brady J., Shawn Regis, Andrea K. Borondy-Kitts, Jeffrey A. Hashim, Robert J. French, Christoph Wald, and Andrea B. McKee. “NCCN Guidelines as a Model of Extended Criteria for Lung Cancer Screening.J Natl Compr Canc Netw 16, no. 4 (April 2018): 444–49. https://doi.org/10.6004/jnccn.2018.7021.
McKee BJ, Regis S, Borondy-Kitts AK, Hashim JA, French RJ, Wald C, et al. NCCN Guidelines as a Model of Extended Criteria for Lung Cancer Screening. J Natl Compr Canc Netw. 2018 Apr;16(4):444–9.
McKee, Brady J., et al. “NCCN Guidelines as a Model of Extended Criteria for Lung Cancer Screening.J Natl Compr Canc Netw, vol. 16, no. 4, Apr. 2018, pp. 444–49. Pubmed, doi:10.6004/jnccn.2018.7021.
McKee BJ, Regis S, Borondy-Kitts AK, Hashim JA, French RJ, Wald C, McKee AB. NCCN Guidelines as a Model of Extended Criteria for Lung Cancer Screening. J Natl Compr Canc Netw. 2018 Apr;16(4):444–449.

Published In

J Natl Compr Canc Netw

DOI

EISSN

1540-1413

Publication Date

April 2018

Volume

16

Issue

4

Start / End Page

444 / 449

Location

United States

Related Subject Headings

  • Risk Factors
  • Retrospective Studies
  • Radiography
  • Practice Guidelines as Topic
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Mass Screening
  • Lung Neoplasms
  • Humans
  • Early Detection of Cancer