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Exercise as Adjunct Therapy in Cancer.

Publication ,  Journal Article
Ashcraft, KA; Warner, AB; Jones, LW; Dewhirst, MW
Published in: Semin Radiat Oncol
January 2019

Data from observational studies indicate that both physical activity as well as exercise (ie, structured physical activity) is associated with reductions in the risk of recurrence and cancer mortality after a diagnosis of certain forms of cancer. Emerging evidence from preclinical studies indicates that physical activity/exercise paradigms regulate intratumoral vascular maturity and perfusion, hypoxia, and metabolism and augments the antitumor immune response. Such responses may, in turn, enhance response to standard anticancer treatments. For instance, exercise improves efficacy of chemotherapeutic agents, and there is rationale to believe that it will also improve radiotherapy response. This review overviews the current preclinical as well as clinical evidence supporting exercise modulation of therapeutic response and postulated biological mechanisms underpinning such effects. We also examine the implications for tumor response to radiation, chemotherapy, and immunotherapy.

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Published In

Semin Radiat Oncol

DOI

EISSN

1532-9461

Publication Date

January 2019

Volume

29

Issue

1

Start / End Page

16 / 24

Location

United States

Related Subject Headings

  • Radiotherapy
  • Oncology & Carcinogenesis
  • Neoplasms
  • Immunotherapy
  • Humans
  • Exercise Therapy
  • Combined Modality Therapy
  • Antineoplastic Agents
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

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Ashcraft, K. A., Warner, A. B., Jones, L. W., & Dewhirst, M. W. (2019). Exercise as Adjunct Therapy in Cancer. Semin Radiat Oncol, 29(1), 16–24. https://doi.org/10.1016/j.semradonc.2018.10.001
Ashcraft, Kathleen A., Allison Betof Warner, Lee W. Jones, and Mark W. Dewhirst. “Exercise as Adjunct Therapy in Cancer.Semin Radiat Oncol 29, no. 1 (January 2019): 16–24. https://doi.org/10.1016/j.semradonc.2018.10.001.
Ashcraft KA, Warner AB, Jones LW, Dewhirst MW. Exercise as Adjunct Therapy in Cancer. Semin Radiat Oncol. 2019 Jan;29(1):16–24.
Ashcraft, Kathleen A., et al. “Exercise as Adjunct Therapy in Cancer.Semin Radiat Oncol, vol. 29, no. 1, Jan. 2019, pp. 16–24. Pubmed, doi:10.1016/j.semradonc.2018.10.001.
Ashcraft KA, Warner AB, Jones LW, Dewhirst MW. Exercise as Adjunct Therapy in Cancer. Semin Radiat Oncol. 2019 Jan;29(1):16–24.
Journal cover image

Published In

Semin Radiat Oncol

DOI

EISSN

1532-9461

Publication Date

January 2019

Volume

29

Issue

1

Start / End Page

16 / 24

Location

United States

Related Subject Headings

  • Radiotherapy
  • Oncology & Carcinogenesis
  • Neoplasms
  • Immunotherapy
  • Humans
  • Exercise Therapy
  • Combined Modality Therapy
  • Antineoplastic Agents
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis